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Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor.Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.Applications of lentiviral vectors for biology and gene therapy of neurological disorders.Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.Piericidin A aggravates Tau pathology in P301S transgenic miceA Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease.Impact of dopamine to serotonin cell ratio in transplants on behavioral recovery and L-DOPA-induced dyskinesia.Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats.Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation.Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease.Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease.Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model.Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice.Cyclophosphamide-induced alterations of the micturition reflex in a novel in situ urinary bladder model in the anesthetized rat.Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease.Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.Impact of dopamine versus serotonin cell transplantation for the development of graft-induced dyskinesia in a rat Parkinson model.Biodistribution and brain permeability of the extracellular domain of neuregulin-1-β1.Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's diseaseA novel in situ urinary bladder model for studying afferent and efferent mechanisms in the micturition reflex in the rat
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Thomas Carlsson
@ast
Thomas Carlsson
@en
Thomas Carlsson
@es
Thomas Carlsson
@nl
Thomas Carlsson
@sl
type
label
Thomas Carlsson
@ast
Thomas Carlsson
@en
Thomas Carlsson
@es
Thomas Carlsson
@nl
Thomas Carlsson
@sl
prefLabel
Thomas Carlsson
@ast
Thomas Carlsson
@en
Thomas Carlsson
@es
Thomas Carlsson
@nl
Thomas Carlsson
@sl
P106
P21
P31
P496
0000-0003-3632-8959