Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach.
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Application of Markov chain Monte Carlo analysis to biomathematical modeling of respirable dust in US and UK coal minersBayesian evaluation of a physiologically-based pharmacokinetic (PBPK) model of long-term kinetics of metal nanoparticles in ratsHuman health effects of trichloroethylene: key findings and scientific issuesTarget Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data GapsAddressing human variability in next-generation human health risk assessments of environmental chemicalsBayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant PopulationsPhysiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.A physiologically based pharmacokinetic model for capreomycin.Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection modelPhysiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsCutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology ParadigmsPhysiologically Based Pharmacokinetic Model of Rifapentine and 25-Desacetyl Rifapentine Disposition in Humans.Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.Characterization of the human kinetic adjustment factor for the health risk assessment of environmental contaminants.A novel approach for estimating ingested dose associated with paracetamol overdose.Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling.Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach.Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.A framework and case studies for evaluation of enzyme ontogeny in children's health risk evaluation.New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures.Challenges Associated with Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making.Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.Modeling and Simulation of Pretomanid Pharmacokinetics in Pulmonary Tuberculosis Patients.Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough.Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling.Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice
P2860
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P2860
Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Characterizing uncertainty and ...... model, and Bayesian approach.
@en
Characterizing uncertainty and ...... model, and Bayesian approach.
@nl
type
label
Characterizing uncertainty and ...... model, and Bayesian approach.
@en
Characterizing uncertainty and ...... model, and Bayesian approach.
@nl
prefLabel
Characterizing uncertainty and ...... model, and Bayesian approach.
@en
Characterizing uncertainty and ...... model, and Bayesian approach.
@nl
P2093
P1476
Characterizing uncertainty and ...... model, and Bayesian approach.
@en
P2093
Marina V Evans
Miles S Okino
Weihsueh A Chiu
P356
10.1016/J.TAAP.2009.07.032
P577
2009-08-04T00:00:00Z