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Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathwayIdentification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assaysIdentification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assaysIdentification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extractsIdentification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validationIdentification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activityBDT: an easy-to-use front-end application for automation of massive docking tasks and complex docking strategies with AutoDock.Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.DecoyFinder: an easy-to-use python GUI application for building target-specific decoy sets.Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies.Procyanidin effects on adipocyte-related pathologies.Molecular fingerprint similarity search in virtual screening.Tools for in silico target fishing.Molecular mimicry of substrate oxygen atoms by water molecules in the beta-amylase active site.Procyanidins modify insulinemia by affecting insulin production and degradation.Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes.Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells.In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract.Inhibitory effects of grape seed procyanidins on foam cell formation in vitro.Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner.In silico identification of red wine catechin binding sites on human and rat serotransferrins.Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells.Differential effects of grape-seed derived procyanidins on adipocyte differentiation markers in different in vivo situationsThe good, the bad and the dubious: VHELIBS, a validation helper for ligands and binding sites.Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin.Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance.Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet.Locating the stabilizing residues in (alpha/beta)8 barrel proteins based on hydrophobicity, long-range interactions, and sequence conservation.Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and ExpressionModulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity ratsA trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidinsErratum to “Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet” [J Nutr Biochem 17 (2006) 139-142]Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activityThe Light and Dark Sides of Virtual Screening: What Is There to Know?Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activityThe lipid-lowering effect of dietary proanthocyanidins in rats involves both chylomicron-rich and VLDL-rich fractionsDevelopment of docking-based 3D-QSAR models for PPARgamma full agonistsCharacterization of the protease activity of detergents: laboratory practicals for studying the protease profile and activity of various commercial detergentsCharacterization of the activity and stability of amylase from saliva and detergent: laboratory practicals for studying the activity and stability of amylase from saliva and various commercial detergentsActivity and selectivity cliffs for DPP-IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening
P50
Q28222550-FF48CB6A-2A0C-4BC7-B2BD-2142F4DAB2EFQ28477268-9EA397A9-006A-4A3C-805C-E00C36FA682FQ28483681-22345648-CB37-4D93-A9FC-258EE22061F0Q28483936-F8F81602-566F-48F7-B5B2-83653881BEEBQ28485402-BDBC9D41-832C-4A59-B7E2-593C2EAF4346Q28486003-A6161A83-DDB8-4CEB-A588-1470C333F281Q33244409-A485F664-9129-47CE-B1A4-6449979E94C6Q34079471-0B1D42D5-148B-4558-8B3C-BE0568297F1FQ34249296-D579106C-064D-4826-9265-44582F124EBAQ34490095-0EE55E9E-8A43-4367-A61C-313D726F47FEQ36586055-B06B0505-3334-474C-809B-8EC17AE498F0Q38240827-BCFFE663-29BB-41D7-B5CB-A7899D9441ACQ38256258-FE1C02BB-2DDD-451E-BA0B-168AEEE775FAQ38272394-33CE9F9E-A42C-411A-8FD5-162545767248Q39374763-2D5808CC-AE2E-4F84-87C3-F0CB2B150934Q39575955-5664F812-CC89-426C-B863-246F255D77E2Q39703671-DF1960E3-8E10-4EC1-8F43-31951DEECD62Q39868865-901F91CE-A18A-4338-B72C-DB8DF9630ADEQ39871873-EA665483-7DA2-49E5-AD08-644B53ABACF1Q39948244-5D237716-2BBD-4B74-8D4D-09B96AB26BD9Q40620789-1CA70C3F-22FB-4EDF-B6A9-038AB29FE361Q40621132-F5E648DB-FE6A-4ED5-801A-43D983C6AA82Q40621772-C9F0D33C-DB1E-48CE-9A6B-C9E5CC3A2A2BQ42538022-B571AD5A-E4BB-4B12-971F-EF972E1BB67FQ42799596-0FD1FEF5-2B95-4637-AA2E-6A1F6CE8908CQ42831607-837F4C43-1035-43A3-8773-5E3269E22435Q46500697-A789A691-9A24-4143-AEB2-2864938D17FAQ47867085-4BBA3E23-C21E-4DD1-BA73-E13EC99BC2A1Q60197832-E2940CE1-3616-48B9-B714-AAF1D6452FC0Q60197862-18946FC8-439D-4ACA-B9D7-B7FF92007E58Q60197882-BFEF5213-3E3E-4B6A-AC37-BC5EE02CA56EQ60197897-7B3A3955-112C-45D2-BFD7-69A12EADB469Q61697352-953630C4-DD1A-4F71-8EEE-3492274C5C21Q64076270-D5C82B10-B2E7-4D9E-AEED-82EE2272FBC7Q82036723-6B48A691-5583-4342-8B7D-365CC46E5561Q82098477-87B29002-5959-451E-B28D-40016E07DF19Q83890710-BD1E2B45-8010-4F82-9D0E-7041188F5E95Q84578424-A50FB470-1C92-4706-B701-6626F2909452Q84583688-4E37809B-8B09-4F8D-BF96-FE8DEB8FFEADQ88373673-35346475-07D9-4D5D-8CB5-AF0F05AD2D27
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Gerard Pujadas
@ast
Gerard Pujadas
@en
Gerard Pujadas
@es
Gerard Pujadas
@nl
Gerard Pujadas
@sl
type
label
Gerard Pujadas
@ast
Gerard Pujadas
@en
Gerard Pujadas
@es
Gerard Pujadas
@nl
Gerard Pujadas
@sl
prefLabel
Gerard Pujadas
@ast
Gerard Pujadas
@en
Gerard Pujadas
@es
Gerard Pujadas
@nl
Gerard Pujadas
@sl
P1053
B-1457-2010
P106
P21
P31
P3829
P496
0000-0003-2598-8089