The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.
about
Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growthSynergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolismThe PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysisOverexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's diseaseInhibitory effect of ubiquitin-proteasome pathway on proliferation of esophageal carcinoma cells.Beta-secretase: structure, function, and evolution.Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression.The proteasome-ubiquitin system is required for efficient killing of intracellular Streptococcus pneumoniae by brain endothelial cellsPhysiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease.Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.Aspartic proteases involved in Alzheimer's disease.Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 miceTranslation of nonSTOP mRNA is repressed post-initiation in mammalian cellsHypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.Therapeutic options in Alzheimer's disease.The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.Human fortilin is a molecular target of dihydroartemisinin.Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase.Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling.γ-Secretase Dependent Nuclear Targeting of Dystroglycan.Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells.Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan.Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein.Akt negatively regulates translation of the ternary complex factor Elk-1.
P2860
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P2860
The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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name
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@en
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@nl
type
label
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@en
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@nl
prefLabel
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@en
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@nl
P2860
P356
P1476
The protease inhibitor, MG132, ...... ng cleavage by beta-Secretase.
@en
P2093
M L Steinhilb
P2860
P304
P356
10.1074/JBC.M008793200
P407
P577
2000-11-17T00:00:00Z