Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
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Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystoniaHow rapidly does the human mitochondrial genome evolve?A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.Leber's hereditary optic neuropathy: correlations between mitochondrial genotype and visual outcome.The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates.Leber hereditary optic neuropathy: Does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation?Mitochondrial genotype segregation in a mouse heteroplasmic lineage produced by embryonic karyoplast transplantation.Random genetic drift determines the level of mutant mtDNA in human primary oocytesA sensitive denaturing gradient-Gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region 1 of the human mtDNA control region.Human mitochondrial genetics.The identification of the Romanovs: Can we (finally) put the controversies to rest?Mitochondrial genetics '98 is the bottleneck cracked?Mitochondrial disorders: genetics, counseling, prenatal diagnosis and reproductive options.Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA.Mitochondrial genotype segregation during preimplantation development in mouse heteroplasmic embryos.Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes.Homopolymeric tract heteroplasmy in mtDNA from tissues and single oocytes: support for a genetic bottleneck.Variable levels of a heteroplasmic point mutation in individual hair rootsSkewed segregation of the mtDNA nt 8993 (T-->G) mutation in human oocytesLength heteroplasmy in the first hypervariable segment of the human mtDNA control region.Rearranged mitochondrial genomes are present in human oocytes.Longitudinal study of a heteroplasmic 3460 Leber hereditary optic neuropathy family by multiplexed primer-extension analysis and nucleotide sequencingHeteroplasmic point mutations in the human mtDNA control region.Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneckComplementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles.Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation.Single-cell analysis of intercellular heteroplasmy of mtDNA in Leber hereditary optic neuropathy.A heteroplasmic LHON family: tissue distribution and transmission of the 11778 mutation.Transmission of mtDNA: cracks in the bottleneck.Understanding differences between phylogenetic and pedigree-derived mtDNA mutation rate: a model using families from the Azores Islands (Portugal).Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.
P2860
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P2860
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@en
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@nl
type
label
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@en
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@nl
prefLabel
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@en
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@nl
P2093
P356
P1433
P1476
Mitochondrial gene segregation in mammals: is the bottleneck always narrow?
@en
P2093
D A McCullough
D M Turnbull
S Halvorson
P2888
P304
P356
10.1007/BF00210753
P577
1992-09-01T00:00:00Z
P6179
1020585782