Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
about
Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicityDeficiency of prion protein induces impaired autophagic flux in neurons.Remarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain.Recruitment of cellular prion protein to mitochondrial raft-like microdomains contributes to apoptosis execution.Dysfunction of microtubule-associated proteins of MAP2/tau family in Prion disease.Cytosolic caspases mediate mislocalised SOD2 depletion in an in vitro model of chronic prion infection.Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss.PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn.The fate of PrP GPI-anchor signal peptide is modulated by P238S pathogenic mutation.Do prion protein gene polymorphisms induce apoptosis in non-mammals?Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants.
P2860
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P2860
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
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2010年學術文章
@zh-hant
name
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@en
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@nl
type
label
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@en
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@nl
prefLabel
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@en
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@nl
P2093
P2860
P1476
Cytosolic PrP induces apoptosis of cell by disrupting microtubule assembly.
@en
P2093
Chen-Fang Dong
Gui-Rong Wang
Ming-Ming Pan
Rui-Min Zhou
Xiao-Li Li
Xiao-Ping Dong
Yuan-Yuan Jing
Zhao-Yun Wang
P2860
P2888
P304
P356
10.1007/S12031-010-9443-9
P577
2010-09-14T00:00:00Z
P6179
1016632147