Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo.
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Serine, glycine and one-carbon units: cancer metabolism in full circleMechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402).Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapyPhase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia.Phase I study of GTI-2040, a ribonucleotide reductase antisense, with high dose cytarabine in patients with relapsed/refractory acute myeloid leukemia.A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer.Synergistic effects of nimesulide and 5-fluorouracil on tumor growth and apoptosis in the implanted hepatoma in mice.Genetic factors influencing pyrimidine-antagonist chemotherapy.MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2.Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.A mathematical feasibility argument for the use of aptamers in chemotherapy and imaging.In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subsetEnhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase.Combination therapy using oral S-1 and targeted agents against human tumor xenografts in nude mice.Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell linesPretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells.Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs.Possible antitumor activity of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line.Prognostic value of ERCC1, RRM1, and TS proteins in patients with resected non-small cell lung cancer.A common telomeric gene silencing assay is affected by nucleotide metabolism.Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.Thymidylate synthase gene expression in primary tumors predicts activity of s-1-based chemotherapy for advanced gastric cancer.Identification of potential pharmacogenomic markers of clinical efficacy of 5-fluorouracil in colorectal cancer.Synthesis and antitumor activity of 5-bromo-1-mesyluracil.Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.
P2860
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P2860
Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Thymidylate synthase (TS) and ...... man cancer xenografts in vivo.
@en
type
label
Thymidylate synthase (TS) and ...... man cancer xenografts in vivo.
@en
prefLabel
Thymidylate synthase (TS) and ...... man cancer xenografts in vivo.
@en
P2093
P1476
Thymidylate synthase (TS) and ...... man cancer xenografts in vivo.
@en
P2093
P304
P356
10.1016/S0959-8049(01)00174-5
P577
2001-09-01T00:00:00Z