Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.
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The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risksThe effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitorsCurcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In VitroPathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathwayER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domainAberrant Ca2+ handling in lysosomal storage disordersStressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas.Discovery of novel SERCA inhibitors by virtual screening of a large compound libraryMultitargeting by curcumin as revealed by molecular interaction studiesCurcumin produces an antihyperalgesic effect via antagonism of TRPV1.Modulation of protein kinase C by curcumin; inhibition and activation switched by calcium ions.Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neuronsThe Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functionalAcidic Ca2+ stores in neurodegeneration.Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer.Natural Compounds as Therapeutic Agents in the Treatment Cystic FibrosisDemethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of LifeCancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?Calcium pumps in health and disease.Natural and synthetic antioxidants: an updated overview.Current controversies in Niemann-Pick C1 disease: steroids or gangliosides; neurons or neurons and glia.Ion pumps as biological targets for decavanadate.Calcium pumps: why so many?How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies.Curcumisome nanovesicles generated by self-assembly of curcumin amphiphiles toward cancer theranostics.Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress.Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells.The Effect of Curcumin on Intracellular pH (pHi), Membrane Hyperpolarization and Sperm Motility.Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin.Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.The inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by macrocyclic lactones and cyclosporin A.Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1.Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.Curcumin Exerts Effects on the Pathophysiology of Alzheimer's Disease by Regulating PI(3,5)P2 and Transient Receptor Potential Mucolipin-1 Expression.Curcumin modulation of Na,K-ATPase: phosphoenzyme accumulation, decreased K+ occlusion, and inhibition of hydrolytic activity.Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment.Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching.
P2860
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P2860
Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@en
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@nl
type
label
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@en
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@nl
prefLabel
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@en
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@nl
P2093
P2860
P1433
P1476
Inhibition of the SERCA Ca2+ p ...... domains in the absence of ATP.
@en
P2093
F Michelangeli
J G Bilmen
P2860
P304
P356
10.1046/J.0014-2956.2001.02589.X
P407
P577
2001-12-01T00:00:00Z