about
Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements.Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.Strategies for design of non peptide CCK1R agonist/antagonist ligands.De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators.D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex.Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction.Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluationDivergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactamExperimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular CatalysisAzepane Quaternary Amino Acids As Effective Inducers of 310 Helix ConformationsQuaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragmentsExceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan DomainAn iterative structure-assisted approach to sequence alignment and comparative modeling
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Mercedes Martín-Martínez
@ast
Mercedes Martín-Martínez
@en
Mercedes Martín-Martínez
@es
Mercedes Martín-Martínez
@nl
Mercedes Martín-Martínez
@sl
type
label
Mercedes Martín-Martínez
@ast
Mercedes Martín-Martínez
@en
Mercedes Martín-Martínez
@es
Mercedes Martín-Martínez
@nl
Mercedes Martín-Martínez
@sl
prefLabel
Mercedes Martín-Martínez
@ast
Mercedes Martín-Martínez
@en
Mercedes Martín-Martínez
@es
Mercedes Martín-Martínez
@nl
Mercedes Martín-Martínez
@sl
P1053
G-7363-2015
P106
P1153
6701462413
P21
P31
P3829
P496
0000-0002-6449-0905