Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin. - Wikidata - wikimedia - TriplyDB

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

http://www.wikidata.org/entity/Q43833680

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Retinopathy in mice induced by disrupted all-trans-retinal clearance Functional roles of bestrophins in ocular epithelia The lipid translocase, ABCA4: seeing is believing.Clinical applications of fundus autofluorescence in retinal disease Chemistry of the retinoid (visual) cycle Exome sequencing analysis identifies compound heterozygous mutation in ABCA4 in a Chinese family with Stargardt disease Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage FUNDUS AUTOFLUORESCENCE LIFETIMES AND CENTRAL SEROUS CHORIORETINOPATHY.Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells.Phospholipid meets all-trans-retinal: the making of RPE bisretinoids Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity.Ultra-widefield fundus autofluorescence in age-related macular degeneration.Synthesis of antioxidants for prevention of age-related macular degeneration Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments.Fundus autofluorescence and the bisretinoids of retina.Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate.Rational Tuning of Visual Cycle Modulator Pharmacodynamics Effects of organic solvents on two retinal pigment epithelial lipofuscin fluorophores, A2E and all-trans-retinal dimer Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid.The retinal pigment epithelium in health and disease Vitamin A dimers trigger the protracted death of retinal pigment epithelium cells Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.Recovery of rod photoresponses in ABCR-deficient mice.Fluorescence lifetime measurements and biological imaging Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration Fundus autofluorescence and photoreceptor cell rosettes in mouse models.Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.High resolution MALDI imaging mass spectrometry of retinal tissue lipids.Fundus autofluorescence findings in a mouse model of retinal detachment.Mass spectrometry provides accurate and sensitive quantitation of A2E.Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments.Evolution of the vertebrate pineal gland: the AANAT hypothesis.A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness Genetics and molecular pathology of Stargardt-like macular degeneration.Therapy for macular degeneration: insights from acne

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P2860

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

http://www.wikidata.org/entity/Q43833680

description

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Biosynthetic studies of A2E, a ...... pigment epithelial lipofuscin.

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Biosynthetic studies of A2E, a ...... pigment epithelial lipofuscin.

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Biosynthetic studies of A2E, a ...... pigment epithelial lipofuscin.

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Craig A Parish

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Heidi R Vollmer

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Janet R Sparrow

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Nathan Fishkin

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Shimon Ben-Shabat

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Yasuhiro Itagaki

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P2860

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy

Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR

Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration

Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR

Characterization of phospholipase D activity in bovine photoreceptor membranes

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase.

The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial.

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10.1074/JBC.M108981200

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