The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
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Ziconotide: a review of its pharmacology and use in the treatment of painBioactive Mimetics of Conotoxins and other Venom PeptidesThe Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialOmega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminalsA long-form alpha-neurotoxin from cobra venom produces potent opioid-independent analgesiaThe alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channelsAnimal models of chronic pain: Advances and challenges for clinical translation.Role of voltage-gated calcium channels in ascending pain pathwaysTargeting chronic and neuropathic pain: the N-type calcium channel comes of age.Conus peptides: biodiversity-based discovery and exogenomics.Discovery and Development of Calcium Channel Blockers.Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil.The application of genomic and molecular data in the treatment of chronic cancer pain.Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channelsDifferential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons.SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons.muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficitsRegulation of voltage-gated calcium channels by proteolysis.The therapeutic potential of Na+ and Ca2+ channel blockers in pain management.Regulation of spinal substance p release by intrathecal calcium channel blockade.Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels.Chemokines: integrators of pain and inflammation.Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthaseSpinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.Targeting voltage-gated calcium channels for neuropathic pain management.Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development.Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference 2007.Therapeutic potential of conopeptides.Omega-conotoxins as experimental tools and therapeutics in pain management.Conotoxin therapeutics: a pipeline for success?Calcium-permeable ion channels in pain signaling.Recent patents on calcium channel blockers: emphasis on CNS diseases.Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain.Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels.Spider peptide Phα1β induces analgesic effect in a model of cancer pain.Comparison of Burrowing and Stimuli-Evoked Pain Behaviors as End-Points in Rat Models of Inflammatory Pain and Peripheral Neuropathic Pain.Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain.Pre- and postsynaptic contributions of voltage-dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons.
P2860
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P2860
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@en
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@nl
type
label
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@en
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@nl
prefLabel
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@en
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@nl
P2093
P1433
P1476
The novel N-type calcium chann ...... ase in rat spinal cord slices.
@en
P2093
Alan D Robertson
Fraser B Ross
Peter J Cabot
P304
P356
10.1016/S0304-3959(01)00436-5
P407
P577
2002-03-01T00:00:00Z