Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. - Wikidata - wikimedia - TriplyDB

Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.

Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.

http://www.wikidata.org/entity/Q44023429

about

NCK2 is significantly associated with opiates addiction in African-origin men The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study Advances in Medications and Tailoring Treatment for Alcohol Use Disorder Medication treatment of different types of alcoholism.Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings.Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.Pharmacogenetics of OPRM1.Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes.A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys Consilient research approaches in studying gene x environment interactions in alcohol research.OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues.Practitioner review: adolescent alcohol use disorders: assessment and treatment issues.A genetic determinant of the striatal dopamine response to alcohol in men Pharmacogenetics of alcohol and alcohol dependence treatment Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.The pharmacogenetics of alcohol use disorder Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment Pharmacogenetic aspects of addictive behaviors Gender-stratified gene and gene-treatment interactions in smoking cessation Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study.A brief history of research on the genetics of alcohol and other drug use disorders.Pharmacogenetic approaches to the treatment of alcohol addiction.Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans.Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment.Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence Adding Genetic Testing to Evidence-Based Guidelines to Determine the Safest and Most Effective Chronic Pain Treatment for Injured Workers Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism.Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.Opioid pharmacogenetics of alcohol addiction.Initial evidence of an association between OPRM1 and adolescent alcohol misuse

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Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.

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Alcoholism: Clinical and Experimental Research

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Huiping Zhang

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John H Krystal

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Joyce Cramer

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VA Cooperative Study #425 Study Group

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P2860

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.

ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies

Interrogating a high-density SNP map for signatures of natural selection

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.

Pharmacological treatment of alcohol dependence: a review of the evidence.

Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: a meta-analysis of randomized controlled trials.

Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor.

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