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Improving biophysical properties of a bispecific antibody scaffold to aid developabilityDynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.Hierarchical formation of disulfide bonds in the immunoglobulin Fc fragment is assisted by protein-disulfide isomerase.The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing.Engineered soluble monomeric IgG1 CH3 domain: generation, mechanisms of function, and implications for design of biological therapeutics.How antibodies foldProteins improving recombinant antibody production in mammalian cells.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Survival and digestibility of orally-administered immunoglobulin preparations containing IgG through the gastrointestinal tract in humansIgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design.Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody CH3 domain.Increased aggregation propensity of IgG2 subclass over IgG1: role of conformational changes and covalent character in isolated aggregates.Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies.Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics.Synthesis and characterization of a functional intact IgG in a prokaryotic cell-free expression system.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Folding and oxidation of the antibody domain C
@nl
Folding and oxidation of the antibody domain C(H)3.
@en
type
label
Folding and oxidation of the antibody domain C
@nl
Folding and oxidation of the antibody domain C(H)3.
@en
prefLabel
Folding and oxidation of the antibody domain C
@nl
Folding and oxidation of the antibody domain C(H)3.
@en
P2093
P1476
Folding and oxidation of the antibody domain C(H)3.
@en
P2093
Fabio Talamo
Gennaro Marino
Johannes Buchner
Marcus Mayer
Margherita Ruoppolo
Michael J W Thies
Stefan Bell
P304
P356
10.1016/S0022-2836(02)00375-3
P407
P577
2002-06-01T00:00:00Z