Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis.
about
The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growthMystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growthAntiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisBrivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibitionBenefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsApoptosis: targets in pancreatic cancerInflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancersFrom targets to treatments: a review of molecular targets in pancreatic neuroendocrine tumorsMicroRNA regulation in cancer-associated fibroblastsGenetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerDeletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancerHedgehog is an early and late mediator of pancreatic cancer tumorigenesisAntagonistic pleiotropy and p53.Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): molecular basis, preclinical data, and counteracting strategies.Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}.Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesisMetformin: a therapeutic opportunity in breast cancer.The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival.Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: implications for tumor angiogenesisNorthwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES.Role of receptor tyrosine kinases and their ligands in glioblastoma.Involvement of members of the cadherin superfamily in cancerInsulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signalingDistinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axisDopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Krüppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylationCoordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.Distinct roles for cysteine cathepsin genes in multistage tumorigenesisSurvival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesisIdentification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis.Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Extracellular molecules involved in cancer cell invasionInhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma.
P2860
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P2860
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@en
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@nl
type
label
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@en
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@nl
prefLabel
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@en
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@nl
P1433
P1476
Elevated levels of IGF-1 recep ...... ancreatic islet tumorigenesis.
@en
P2093
Douglas Hanahan
Theresa Lopez
P304
P356
10.1016/S1535-6108(02)00055-7
P577
2002-05-01T00:00:00Z