about
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches.Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.Chemical probes for the recognition of cannabinoid receptors in native systems.Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.Therapeutic perspectives of inhibitors of endocannabinoid degradation.The medicinal chemistry of agents targeting monoacylglycerol lipase.A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington's disease.Ligand chain length drives activation of lipid G protein-coupled receptors.New inhibitors of angiogenesis with antitumor activity in vivo.Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer.Development of Fluorescent Ligands for the Human 5-HT1A Receptor.The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.New synthetic inhibitors of fatty acid synthase with anticancer activity.Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.Development of molecular probes for the human 5-HT(6) receptor.2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination.Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways.Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study.The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation.UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors.Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin.Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures.Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis.Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels.A fluorescent probe to unravel functional features of cannabinoid receptor CB1 in human blood and tonsil immune system cells.Endocannabinoids drive the acquisition of an alternative phenotype in microglia.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.Neurochemical effects of the endocannabinoid uptake inhibitor UCM707 in various rat brain regions.Blocking Ras inhibition as an antitumor strategy.Mitochondrial CB₁ receptors regulate neuronal energy metabolism.Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.Unique pharmacological properties of serotonergic G-protein coupled receptors from cestodes.2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Silvia Ortega-Gutiérrez
@ast
Silvia Ortega-Gutiérrez
@en
Silvia Ortega-Gutiérrez
@es
Silvia Ortega-Gutiérrez
@nl
Silvia Ortega-Gutiérrez
@sl
type
label
Silvia Ortega-Gutiérrez
@ast
Silvia Ortega-Gutiérrez
@en
Silvia Ortega-Gutiérrez
@es
Silvia Ortega-Gutiérrez
@nl
Silvia Ortega-Gutiérrez
@sl
prefLabel
Silvia Ortega-Gutiérrez
@ast
Silvia Ortega-Gutiérrez
@en
Silvia Ortega-Gutiérrez
@es
Silvia Ortega-Gutiérrez
@nl
Silvia Ortega-Gutiérrez
@sl
P1053
I-1935-2017
P106
P21
P31
P3829
P496
0000-0002-0257-6754