Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase.
about
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complexPhylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthaseCrystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A FLEXIBLE MOLECULE WITH TWO INTERCONNECTED ACTIVE SITESFirst Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingSubstrate tunnels in enzymes: structure-function relationships and computational methodologyBrownian dynamics simulations of aldolase binding glyceraldehyde 3-phosphate dehydrogenase and the possibility of substrate channelingContinuum diffusion reaction rate calculations of wild-type and mutant mouse acetylcholinesterase: adaptive finite element analysis.Electrostatic channeling in P. falciparum DHFR-TS: Brownian dynamics and Smoluchowski modeling.Biological channeling of a reactive intermediate in the bifunctional enzyme DmpFG.Enzyme localization, crowding, and buffers collectively modulate diffusion-influenced signal transduction: Insights from continuum diffusion modeling.Computational methods for biomolecular electrostatics.Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian dynamics studiesEssential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains.A model study of sequential enzyme reactions and electrostatic channeling.Substrate channelling as an approach to cascade reactions.Substrate channeling between the human dihydrofolate reductase and thymidylate synthase.Atomistic simulations of competition between substrates binding to an enzyme.Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics.NAD(H) recycling activity of an engineered bifunctional enzyme galactose dehydrogenase/lactate dehydrogenaseEnantioselective reduction of prochiral ketones by engineered bifunctional fusion proteins.Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity.Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior.Cellular automata models of chemical systems.Simulation of intermediate transport in nanoscale scaffolds for multistep catalytic reactions.Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A.
P2860
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P2860
Electrostatic channeling in the bifunctional enzyme dihydrofolate reductase-thymidylate synthase.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@en
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@nl
type
label
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@en
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@nl
prefLabel
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@en
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@nl
P2093
P356
P1476
Electrostatic channeling in th ...... eductase-thymidylate synthase.
@en
P2093
Knighton DR
Matthews DA
McCammon JA
P304
P356
10.1006/JMBI.1996.0520
P407
P577
1996-09-01T00:00:00Z