Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.
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The search for novel analgesics: targets and mechanismsMolecular and functional properties of P2X receptors--recent progress and persisting challengesNociceptive transmission and modulation via P2X receptors in central pain syndromeP2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATPTRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neuronsDeletion of P2X3 receptors blunts gastro-oesophageal sensation in mice.A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory painDevelopment, plasticity and modulation of visceral afferents.P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord.Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels.The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1).P2X3 receptors and peripheral pain mechanisms.The role of mesopontine NGF in sleep and wakefulness.Purinoceptors as therapeutic targets for lower urinary tract dysfunction.Crossing the pain barrier: P2 receptors as targets for novel analgesics.ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptorsModulation of P2X3 and P2X2/3 Receptors by Monoclonal AntibodiesP2 receptors and chronic painFunctional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion.Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.Therapeutic potential of RNA interference in pain medicinePurinergic mechanosensory transduction and visceral pain.TNF-alpha and neuropathic pain--a review.A chronic pain: inflammation-dependent chemoreceptor adaptation in rat carotid body.Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?In Vivo application of RNAi to study pain.The purinergic system and glial cells: emerging costars in nociception.Current and Future Issues in the Development of Spinal Agents for the Management of Pain.siRNA relieves chronic neuropathic painNeuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase CIndependent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor.AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats.Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body.Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory painA role for the purinergic receptor P2X3 in astrocytes in the mechanism of craniofacial neuropathic pain.Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats.
P2860
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P2860
Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Functional downregulation of P ...... opathic and inflammatory pain.
@en
Functional downregulation of P ...... opathic and inflammatory pain.
@nl
type
label
Functional downregulation of P ...... opathic and inflammatory pain.
@en
Functional downregulation of P ...... opathic and inflammatory pain.
@nl
prefLabel
Functional downregulation of P ...... opathic and inflammatory pain.
@en
Functional downregulation of P ...... opathic and inflammatory pain.
@nl
P2093
P921
P1476
Functional downregulation of P ...... ropathic and inflammatory pain
@en
P2093
Alyson Fox
Francois Natt
Gabriele Dorn
Glen Wotherspoon
Jane Barclay
Janet Winter
Jonathan Hall
Louise Eunson
Sadhana Patel
P304
P356
10.1523/JNEUROSCI.22-18-08139.2002
P407
P50
P577
2002-09-01T00:00:00Z