DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. - Wikidata - wikimedia - TriplyDB

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

http://www.wikidata.org/entity/Q44165063

about

Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer Regulation of human p53 activity and cell localization by alternative splicing p53 isoforms can regulate p53 transcriptional activity.The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop The C terminus of p53 family proteins is a cell fate determinant Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphisms Uncovering the role of p53 splice variants in human malignancy: a clinical perspective p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept NT4(Si)-p53(N15)-antennapedia induces cell death in a human hepatocellular carcinoma cell line Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells Influence of Matrices on 3D-Cultured Prostate Cancer Cells' Drug Response and Expression of Drug-Action Associated Proteins Modulation of mammalian life span by the short isoform of p53.Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53.Antagonistic pleiotropy and p53.Running on empty: how p53 controls INS/IGF signaling and affects life span p53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos Tumor suppression by p53: making cells senescent.Involvement of nuclear export in human papillomavirus type 18 E6-mediated ubiquitination and degradation of p53.p53 Isoforms: An Intracellular Microprocessor?PIN3 duplication may be partially responsible for TP53 haploinsufficiency The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome.p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts Two internal ribosome entry sites mediate the translation of p53 isoforms.Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53.Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice.Altered expression of Ano1 variants in human diabetic gastroparesis p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.Ubiquitin and ubiquitin-like modifications of the p53 family.p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.p53 in stem cells p53 Family: Role of Protein Isoforms in Human Cancer.Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.

P2860

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P2860

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

http://www.wikidata.org/entity/Q44165063

description

2002 nî lūn-bûn

@nan

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

2002年學術文章

@zh-hant

name

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@en

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@nl

type

label

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@en

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@nl

prefLabel

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@en

DeltaN-p53, a natural isoform ...... suppression by wild-type p53.

@nl

P1433

Q44165063-4AB1F662-4816-43C0-8F49-542414C4A6FA

P1476

Q44165063-040086D2-48EE-411A-944D-CD47114BA732

P2093

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Q44165063-E0D4F486-62A9-4BB0-8CCE-C26FA2B4BCA7

P2860

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P2888

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P31

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P356

Q44165063-2C010BCD-F416-4273-A2BF-A6FCB08EFDBE

P407

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P433

Q44165063-D7021717-03D6-4783-8000-E21EF0FCDF37

P478

Q44165063-FAE9E56A-7115-4A4E-97F8-76809F3E4461

P50

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P577

Q44165063-0AD0CC41-50CB-4BD2-86D4-825EF4166E91

P698

Q44165063-88C1710C-CD8E-4981-A6D7-188705DEC190

P356

P1433

P1476

DeltaN-p53, a natural isoform ...... h suppression by wild-type p53

@en

P2093

Gerald Verhaegh

http://www.w3.org/2001/XMLSchema#string

Maria-Gloria Luciani

http://www.w3.org/2001/XMLSchema#string

Moshe Oren

http://www.w3.org/2001/XMLSchema#string

Patrice Lassus

http://www.w3.org/2001/XMLSchema#string

Sophie North

http://www.w3.org/2001/XMLSchema#string

Stéphanie Courtois

http://www.w3.org/2001/XMLSchema#string

Ula Hibner

http://www.w3.org/2001/XMLSchema#string

P2860

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

Mdm2 promotes the rapid degradation of p53

Control of cell cycle progression by c-Jun is p53 dependent

Regulation of p53 stability by Mdm2

Activation and activities of the p53 tumour suppressor protein

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

p63 is a p53 homologue required for limb and epidermal morphogenesis

P2888

P304

6722-6728

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.ONC.1205874

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P407

P433

44

http://www.w3.org/2001/XMLSchema#string

P478

21

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P50

P577

2002-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12360399

http://www.w3.org/2001/XMLSchema#string