Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. - Wikidata - wikimedia - TriplyDB

Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.

Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.

http://www.wikidata.org/entity/Q44213356

about

Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist Current and future regenerative medicine - principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine Temporal expression and tissue distribution of interleukin-1β in two strains of guinea pigs with varying propensity for spontaneous knee osteoarthritis.Augmentation Strategies following the Microfracture Technique for Repair of Focal Chondral Defects.Microfracture: Basic Science Studies in the Horse.Clinical potential and challenges of using genetically modified cells for articular cartilage repair.Interaction between osteoarthritic chondrocytes and adipose-derived stem cells is dependent on cell distribution in three-dimension and transforming growth factor-β3 induction Comparison of hIGF-1 gene transfection to the hBMSCs and human meniscal fibrochondrocytes.Effects of phosphorylatable short peptide-conjugated chitosan-mediated IL-1Ra and igf-1 gene transfer on articular cartilage defects in rabbits.Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.Major biological obstacles for persistent cell-based regeneration of articular cartilage.Gene therapy for articular cartilage repair.Concepts in gene therapy for cartilage repair.Cartilage repair: past and future--lessons for regenerative medicine.Enhanced meniscal repair by overexpression of hIGF-1 in a full-thickness model.Controlled delivery systems: from pharmaceuticals to cells and genes.The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine.Management of articular cartilage defects of the knee.Controlled release strategies for bone, cartilage, and osteochondral engineering--Part II: challenges on the evolution from single to multiple bioactive factor delivery.Advances and challenges in gene-based approaches for osteoarthritis.Use of tissue engineering strategies to repair joint tissues in osteoarthritis: viral gene transfer approaches.Genetically modified chondrocytes expressing TGF-β1: a revolutionary treatment for articular cartilage damage?Cartilage tissue engineering: recent advances and perspectives from gene regulation/therapy.Gene Therapy for Cartilage Repair.Equine Models of Articular Cartilage Repair Advanced Strategies for Articular Cartilage Defect Repair.Gene therapy for human osteoarthritis: principles and clinical translation.Stem cells and gene therapy for cartilage repair.Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.Combination of baculovirus-expressed BMP-2 and rotating-shaft bioreactor culture synergistically enhances cartilage formation.Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor.In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis.Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model.Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer.Targeted gene therapy of autoimmune diseases: advances and prospects.

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Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.

http://www.wikidata.org/entity/Q44213356

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P2860

IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints.

Biological role of interleukin 1 receptor antagonist isoforms

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.

Effect of purified human interleukin-1 on cartilage degradation.

Elongation factor Tu as a control gene for mRNA analysis of lung development and other differentiation and growth regulated systems.

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene.

Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector.

A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores.

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