ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.
about
Biologic complexity in sickle cell disease: implications for developing targeted therapeuticsDrugs for preventing red blood cell dehydration in people with sickle cell diseaseMagnesium for treating sickle cell diseaseDrugs for preventing red blood cell dehydration in people with sickle cell diseaseDrugs for preventing red blood cell dehydration in people with sickle cell diseaseK+ channels as targets for specific immunomodulationThe intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humansIon channels and transporters in lymphocyte function and immunityPotassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal diseaseMagnesium for treating sickle cell diseaseEpigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer.Treating sickle cell disease by targeting HbS polymerizationNS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells.Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitisDeconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion.The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosisPharmacotherapy in sickle cell disease--state of the art and future prospectsHuman lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channelsDisruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial CellsPotassium channel subtypes as molecular targets for overactive bladder and other urological disorders.Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.Ion transport pathology in the mechanism of sickle cell dehydration.Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?Osteoarticular involvement in sickle cell disease.The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype).Investigational agents for sickle cell disease.The genomics of new drugs in sickle cell disease.Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease.A non-electrolyte haemolysis assay for diagnosis and prognosis of sickle cell disease.N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytesStrain-specific variations in cation content and transport in mouse erythrocytes.KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells
P2860
Q21284789-AF4537E1-5D70-4A1B-B20C-E57041E5594FQ24186046-E5E3E18B-41E7-48AC-B2B9-78816DAB4C17Q24193246-C3101905-A6E2-42B8-A3CA-55547070A395Q24202032-7FE0C4E3-E12D-431E-860A-A46937ABEF79Q24240777-0040A596-DA55-43FD-9448-C7B7F4C8EEC7Q24648323-AFBDC3F6-055A-4FEF-BCD1-332CE4A18789Q24648765-B4732FEC-8DE3-42B1-8345-C7305F2F2D9CQ26829714-D22985F7-9DE3-4DA7-BB0F-FB02226A23A8Q28252713-B738B8EF-074C-4C2A-90B6-71444473A7EEQ29994630-AC4F173B-647D-4EDA-9AEC-D69CC12B8A0AQ30316755-01291774-4422-41CB-AA99-0326436D8AD8Q33707352-54969F84-0A31-45D8-BE3B-D7EEE4BC28DDQ34293957-8CACE1E6-6CAB-4161-B7B4-E1AD762BBF3EQ34433518-A572C2F3-713C-4645-8BDE-A573D08B8997Q34437894-6547640B-AB5F-4857-BE17-107F46E81C28Q34579250-367F0497-BA7F-42F2-96C0-87DB22C4ECC6Q34677065-6071078A-D3E2-4B20-9BE0-7CAAC8315A1DQ34941213-B434BD8C-3CD2-4203-B39E-859D32B181BFQ35083097-D2881EB2-5CAC-429E-8888-428C9B4BF22FQ35220342-D152A231-A986-49D0-AE07-38A25BB6C2CBQ35232951-842F72D3-0691-45CF-A6B8-763ECEF7C08AQ35785736-59C225D6-DD8C-4FD1-B4C3-80292B958DBAQ35848022-29521499-0674-406C-97B0-FC6F1027186CQ35874185-8CF9B859-BE90-4672-8D18-958076D88C2AQ35911129-286348A4-5EC7-46C1-87C3-90098BADF487Q35944615-0BB89A68-023A-47DB-AED8-AC5EB2D67C3BQ35993299-04C5F646-D6A9-48B7-AFFA-000033A0307CQ36269118-F557D4CD-F98F-4318-A36D-04004C9C07C2Q36283152-9132F558-89AB-4915-98C8-8FD135BF24CFQ36438976-E067B4C8-76F2-4193-98BA-9645292A5400Q36534381-7EAC6730-6735-45E2-9212-CAB7887A5523Q36540959-E941C616-8ACE-4F74-9056-C8160C8C2B16Q36543049-B3A77B41-9E2B-4A6B-A29F-70FBF89861F9Q36596719-29E25FDA-3093-4399-A320-C04C8796F120Q36596855-757F4168-5E54-4114-BD96-47756922F234Q36713158-DDC7EBAC-5A48-4A0F-A208-F5AF79317317Q36823889-E239CDCD-635D-473A-B4B5-1E329FB2AA9DQ36850738-99D4EFE7-D38F-42BE-BC96-EF63A421DE48Q37118983-12D3BB06-90E7-40DA-989F-733FD0BFEB87Q37121905-86A88B71-1A0E-47D7-B62B-090C0C2D45A7
P2860
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@en
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@nl
type
label
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@en
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@nl
prefLabel
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@en
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@nl
P2093
P1433
P1476
ICA-17043, a novel Gardos chan ...... vitro and in vivo in SAD mice.
@en
P2093
Carlo Brugnara
Grant A McNaughton-Smith
Jonathan W Stocker
Lucia De Franceschi
Roberto Corrocher
Yves Beuzard
P304
P356
10.1182/BLOOD-2002-05-1433
P407
P577
2002-11-14T00:00:00Z