Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor.
about
A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptorA Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorAnalysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes.Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.Ligand-stabilized conformational states of human beta(2) adrenergic receptor: insight into G-protein-coupled receptor activation.GPCR agonist binding revealed by modeling and crystallography.Stereoselective binding of agonists to the β2-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations.Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site.Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation.
P2860
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P2860
Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor.
description
2002 nî lūn-bûn
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name
Mutation of Asn293 to Asp in t ...... stitutive activity of the beta
@nl
Mutation of Asn293 to Asp in t ...... e beta(2)-adrenergic receptor.
@en
type
label
Mutation of Asn293 to Asp in t ...... stitutive activity of the beta
@nl
Mutation of Asn293 to Asp in t ...... e beta(2)-adrenergic receptor.
@en
prefLabel
Mutation of Asn293 to Asp in t ...... stitutive activity of the beta
@nl
Mutation of Asn293 to Asp in t ...... e beta(2)-adrenergic receptor.
@en
P356
P1476
Mutation of Asn293 to Asp in t ...... e beta(2)-adrenergic receptor.
@en
P2093
Annette Hannawacker
P304
P356
10.1124/MOL.62.6.1431
P577
2002-12-01T00:00:00Z