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A computational framework for the automated construction of glycosylation reaction networksScaling down the size and increasing the throughput of glycosyltransferase assays: activity changes on stem cell differentiationImmune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion.Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium.Platelet GpIba binding to von Willebrand Factor under fluid shear:contributions of the D′D3-domain, A1-domain flanking peptide and O-linked glycans.Cell surface glycoengineering improves selectin-mediated adhesion of mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs): Pilot validation in porcine ischemia-reperfusion model.PPLATE: a computer program for analysis of parallel-plate flow chamber experimental data.Integration of systems glycobiology with bioinformatics toolboxes, glycoinformatics resources, and glycoproteomics data.Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity.Detection of site-specific glycosylation in proteins using flow cytometry.von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activationThe use of surface immobilization of P-selectin glycoprotein ligand-1 on mesenchymal stem cells to facilitate selectin mediated cell tethering and rollingST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.Overexpression of α2,3sialyl T-antigen in breast cancer determined by miniaturized glycosyltransferase assays and confirmed using tissue microarray immunohistochemical analysis.Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.Functionalization of cobalt porphyrin-phospholipid bilayers with his-tagged ligands and antigens.Systems glycobiology: biochemical reaction networks regulating glycan structure and function.Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II.Transport features, reaction kinetics and receptor biomechanics controlling selectin and integrin mediated cell adhesion.von Willebrand factor (VWF) propeptide binding to VWF D'D3 domain attenuates platelet activation and adhesionSulfonated Polyethylenimine for Photosensitizer Conjugation and TargetingSilencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.Glycosylation Network Analysis Toolbox: a MATLAB-based environment for systems glycobiology.Systems-level studies of glycosyltransferase gene expression and enzyme activity that are associated with the selectin binding function of human leukocytes.Systems-level modeling of cellular glycosylation reaction networks: O-linked glycan formation on natural selectin ligands.Fluid shear induces conformation change in human blood protein von Willebrand factor in solution.Application of fluorescence spectroscopy to quantify shear-induced protein conformation change.Understanding glycomechanics using mathematical modeling: a review of current approaches to simulate cellular glycosylation reaction networks.Solution structure of human von Willebrand factor studied using small angle neutron scattering.Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin.Analysis of the specificity of sialyltransferases toward mucin core 2, globo, and related structures. identification of the sialylation sequence and the effects of sulfate, fucose, methyl, and fluoro substituents of the carbohydrate chain in the bioCooperativity between selectins and beta2-integrins define neutrophil capture and stable adhesion in shear flow.Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin-Dependent Rolling in the Multistep Leukocyte Adhesion CascadeA systematic analysis of acceptor specificity and reaction kinetics of five human α(2,3)sialyltransferases: Product inhibition studies illustrate reaction mechanism for ST3Gal-I.Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension.Differential regulation of neutrophil CD18 integrin function by di- and tri-valent cations: manganese vs. gadolinium.An analysis tool to quantify the efficiency of cell tethering and firm-adhesion in the parallel-plate flow chamber.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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Sriram Neelamegham
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P106
P1153
7003813367
P2456
P31
P496
0000-0002-1371-8500