Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.
about
MDM2 negatively regulates the human telomerase RNA gene promoterTelomere and Telomerase Therapeutics in CancerTherapeutic targeting of replicative immortalityThymosin β10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS productionEstablishment of a transgenic zebrafish line for superficial skin ablation and functional validation of apoptosis modulators in vivoThe Plasmodium circumsporozoite protein, a novel NF-κB inhibitor, suppresses the growth of SW480Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector.Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.The importance of the telomere and telomerase system in hematological malignancies.Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies.Targeting telomerase for cancer therapeuticsTelomerase inhibition in cancer therapeutics: molecular-based approachesTelomerase-specific oncolytic virotherapy for human hepatocellular carcinoma.Identification of an RNA aptamer binding hTERT-derived peptide and inhibiting telomerase activity in MCF7 cells.The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines.Modifications to the INSM1 promoter to preserve specificity and activity for use in adenoviral gene therapy of neuroendocrine carcinomas.An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors.Replication-deficient rSV40 mediate pancreatic gene transfer and long-term inhibition of tumor growth.Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene.Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms.The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression.Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement.Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours.Plasmodium circumsporozoite protein suppresses the growth of A549 cells via inhibiting nuclear transcription factor κB.
P2860
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P2860
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Selective ablation of human ca ...... sing bacterial nitroreductase.
@en
Selective ablation of human ca ...... sing bacterial nitroreductase.
@nl
type
label
Selective ablation of human ca ...... sing bacterial nitroreductase.
@en
Selective ablation of human ca ...... sing bacterial nitroreductase.
@nl
prefLabel
Selective ablation of human ca ...... sing bacterial nitroreductase.
@en
Selective ablation of human ca ...... sing bacterial nitroreductase.
@nl
P2093
P2860
P921
P356
P1433
P1476
Selective ablation of human ca ...... sing bacterial nitroreductase.
@en
P2093
Aileen J Fletcher-Monaghan
Claire J Anderson
Fiona McGregor
Jane A Plumb
Richard J Knox
T R Jeffry Evans
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206168
P407
P577
2003-01-01T00:00:00Z
P5875
P6179
1018915984