P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.
about
Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytesLKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytesKnocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretionMembrane transporters in drug developmentHemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitroGene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissuesSandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.Regulation of hepatic ABCC transporters by xenobiotics and in disease states.Intracellular drug bioavailability: a new predictor of system dependent drug disposition.Knocking down transport: applications of RNA interference in the study of drug transport proteins.Methods to evaluate biliary excretion of drugs in humans: an updated review.Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates.Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicityEffect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes.Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytesRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Prediction of human pharmacokinetics-biliary and intestinal clearance and enterohepatic circulation.Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug InteractionsInhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate.Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.Organotypic systems in drug metabolism and toxicity: challenges and opportunities.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.In vitro methods to support transporter evaluation in drug discovery and development.Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport.An evaluation of the latest in vitro tools for drug metabolism studies.Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich-cultured human hepatocytes.A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG Cell CulturesMorphological and Functional Analysis of Hepatocyte Spheroids Generated on Poly-HEMA-Treated Surfaces under the Influence of Fetal Calf Serum and Nonparenchymal Cells.In vitro-in vivo correlation of hepatobiliary drug clearance in humans.In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro.Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver.In vitro metabolism of thyroxine by rat and human hepatocytes.Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.
P2860
Q24649164-EBB394F7-968B-4CE3-8A33-5370B9E888C5Q27315222-78D92AF8-708E-4C10-9A87-774441E0FFDAQ28570070-B8CAEC1B-AE4C-4EC7-A80B-5B985609B3B2Q29616802-8536E47A-857D-466D-B1C9-9197F73C5162Q30412693-41CB7619-BE7B-4DAF-A7F4-F71B576436D7Q34280418-A23DC507-6B36-47B3-8070-47E0B9831484Q34330504-EBA92574-4F18-4535-9F0E-9CBDAD63A863Q34990717-AA4EAC46-E482-4D5D-8C8C-B02DA69A9B31Q35607383-2665F98F-EE25-4087-9D95-AAE4F856ACBAQ35690177-1B4C6EA5-7567-4588-8239-41DFB6074AE4Q36287236-3F414A40-38F0-4FEB-A78C-6A8693D42EA3Q36360814-0727F214-940A-410E-B499-8C444E8BD9B4Q36495774-758C901F-099C-4297-B6E5-B451030AA1B7Q36544962-E9596C56-D596-44A9-B384-ECBAB26CDE55Q36877307-90431611-F557-4C83-B492-258C0B7D2E45Q36948681-9A801D19-5865-4250-8FE7-0AE55CD9732AQ36953118-631531EC-CF4F-4F15-BA60-0AA64C0906A3Q36972804-9281D7B0-0A16-4133-80A7-046AECF93D8DQ37103935-3E6ED28A-BC8F-4E6C-9909-6D83B9F35F7DQ37121662-03F24F13-80F3-4E8F-A951-6FC710B75394Q37139856-45345A06-C595-4C7E-AF97-7A0D2BA66FD6Q37145705-EC1ABDDF-0924-4F18-879D-3C12319CB7F9Q37159255-B40D3372-7523-4EE2-A042-35E5FD81F10FQ37188002-C350C539-D404-494C-88F8-B3A60D5FD933Q37604385-EB11B6ED-9EE4-4265-B1A6-8EAC6CB04476Q38013255-8BDC93C0-00FE-401C-9A13-C87D850FD92EQ38077993-DD7B20F7-A917-4613-AF8A-A63C4726EAC9Q38099194-451CD23F-BED9-455A-AD10-30F930165B64Q38153196-544496BE-860A-43BA-A505-D6E23E693AFFQ38160881-68424EB4-EC9D-4B23-8EB6-03E676A909D9Q38626000-656B92A1-B4EA-47CC-AC3C-DEAF5971D929Q39018278-08E4BE8E-9EDC-41E1-8BDE-318D4F4E6633Q39659058-E4F797A9-4744-4130-BA75-D6F4B39CA037Q39869760-2E2E51F8-3FF6-4ACC-90D9-B3C7C95EF566Q40250598-E48F578D-9465-4BCB-861A-09AEA2DE8D3EQ41812734-1C55C3FD-F9AB-4262-A221-E116EB2BBEFBQ41978560-79DE6B4E-A258-476F-8126-E1AE26E4D6C8Q42437095-11C5D862-FFBA-43C2-A99F-65E0E5A62D5DQ42447513-30431051-A28C-47DE-9197-0AC427961815Q42700015-F51E8A83-7E75-4719-8020-13AEC590809D
P2860
P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@en
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@nl
type
label
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@en
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@nl
prefLabel
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@en
P-glycoprotein expression, loc ...... ion of a model opioid peptide.
@nl
P2093
P1476
P-glycoprotein expression, loc ...... tion of a model opioid peptide
@en
P2093
Keith A Hoffmaster
Peter J Meier
Richard B Kim
Ryan Z Turncliff
P304
P356
10.1023/B:PHAM.0000033018.97745.0D
P577
2004-07-01T00:00:00Z