Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
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P1343
The role of FLT3 in haematopoietic malignanciesStructural and functional alterations of FLT3 in acute myeloid leukemiaActivation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalizationIdentification of AML1-ETO modulators by chemical genomicsA DNA microarray survey of gene expression in normal human tissues.Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaONCOMINE: a cancer microarray database and integrated data-mining platformHox expression in AML identifies a distinct subset of patients with intermediate cytogeneticsMutant FLT3 signaling contributes to a block in myeloid differentiationReversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cellsSelective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cellsExpression genomics and cancer biology.Genetic rearrangement MLL/AF4 is most frequent in children with acute lymphoblastic leukemias in Mexico City.Proteomic and genetic approaches identify Syk as an AML target.High-risk childhood acute lymphoblastic leukemiaLong-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000).FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.Smac mimetics: implications for enhancement of targeted therapies in leukemiaChildren's Oncology Group's 2013 blueprint for research: acute lymphoblastic leukemia.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.FLT3 Internal Tandem Duplication and D835 Mutations in Patients with Acute Lymphoblastic Leukemia and its Clinical SignificancemiR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemiaInhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinibVDA, a method of choosing a better algorithm with fewer validationsMLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.Ensemble Classification of Cancer Types and Biomarker IdentificationThe Biology and Targeting of FLT3 in Pediatric Leukemia.Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype.Interleukin-3 receptor in acute leukemia.Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.Treatment of FLT3-ITD acute myeloid leukemia.Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors.Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia.Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signalingCurrent and potential uses for DNA microarrays in transplantation medicine: lessons from other disciplines.Origins of chromosome translocations in childhood leukaemia.
P2860
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P2860
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@en
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@nl
type
label
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@en
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@nl
prefLabel
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@en
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@nl
P2093
P1433
P1476
Inhibition of FLT3 in MLL. Val ...... pression based classification.
@en
P2093
James D Griffin
John H Kersey
Jonathan A Fletcher
Lewis B Silverman
Meghann E Mabon
Monique L Den Boer
Ronald W Stam
Scott A Armstrong
Stanley J Korsmeyer
Stephen E Sallan
P304
P356
10.1016/S1535-6108(03)00003-5
P4510
P577
2003-02-01T00:00:00Z