Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor.
about
Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancerRole of pregnane X receptor in chemotherapeutic treatmentSustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor ActivationUp-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-ADRifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesPregnane X receptor and natural products: beyond drug-drug interactionsNuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45BGlucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Alterations in xenobiotic metabolism in the long-lived Little mice.Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinomaActivation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.High glucose decreases expression and activity of p-glycoprotein in cultured human retinal pigment epithelium possibly through iNOS induction.Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissuesRegulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophageFunctional interactions between P-glycoprotein and CYP3A in drug metabolism.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARPost-translational modification of pregnane x receptor.Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA.Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differentlyNuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Transcription factor-mediated regulation of carboxylesterase enzymes in livers of miceModulation of p-glycoprotein transport function at the blood-brain barrier.A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liverGenome-wide approaches for identification of nuclear receptor target genes.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor.Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.Expression of the PXR gene in various types of cancer and drug resistanceGenomic profiling in nuclear receptor-mediated toxicity.Functional genomics approaches to studies of the cytochrome p450 superfamily.The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes.
P2860
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P2860
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Genetic profiling defines the ...... receptor pregnane X receptor.
@en
Genetic profiling defines the ...... receptor pregnane X receptor.
@nl
type
label
Genetic profiling defines the ...... receptor pregnane X receptor.
@en
Genetic profiling defines the ...... receptor pregnane X receptor.
@nl
prefLabel
Genetic profiling defines the ...... receptor pregnane X receptor.
@en
Genetic profiling defines the ...... receptor pregnane X receptor.
@nl
P2093
P356
P1476
Genetic profiling defines the ...... receptor pregnane X receptor.
@en
P2093
John M Rosenfeld
Reynaldo Vargas
P304
P356
10.1210/ME.2002-0421
P577
2003-03-27T00:00:00Z