Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. - Wikidata - wikimedia - TriplyDB

Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.

Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.

http://www.wikidata.org/entity/Q44432695

about

Immunotherapy for tuberculosis: future prospects Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?Development of autophagy inducers in clinical medicine Therapeutic targeting of autophagy: potential and concerns in treating cardiovascular disease Therapeutic targeting of autophagy in neurodegenerative and infectious diseases Adjunct Strategies for Tuberculosis Vaccines: Modulating Key Immune Cell Regulatory Mechanisms to Potentiate Vaccination Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis.Current and Emerging Uses of Statins in Clinical Therapeutics: A Review Cell death and autophagy in tuberculosis New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.Statins increase rifampin mycobactericidal effect.Advancing host-directed therapy for tuberculosis.Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment.Autophagy in the fight against tuberculosis.Autophagy in Mycobacterium tuberculosis and HIV infections Statin use associated with a reduced risk of pneumonia requiring hospitalization in patients with myocardial infarction: a nested case-control study.KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus.Targeting Batf2 for infectious diseases and cancer.Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction Is There Potential for Repurposing Statins as Novel Antimicrobials?Statin adjunctive therapy shortens the duration of TB treatment in mice.Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice.Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy The Role of Secretory Autophagy in Zika Virus Transfer through the Placental Barrier.Elevated Cholesterol in the Coxiella burnetii Intracellular Niche Is Bacteriolytic.Statin treatment is associated with a decreased risk of active tuberculosis: an analysis of a nationally representative cohort.Host-Directed Therapies for Tuberculosis.Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions.Methods for Measuring Autophagy in Mice Statin Decreases Helicobacter pylori Burden in Macrophages by Promoting Autophagy Potential effect of ezetimibe against Mycobacterium tuberculosis infection in type II diabetes.The lung is protected from spontaneous inflammation by autophagy in myeloid cells Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense.

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P2860

Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.

http://www.wikidata.org/entity/Q44432695

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2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

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name

Statin therapy reduces the myc ...... hagy and phagosome maturation.

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Statin therapy reduces the myc ...... hagy and phagosome maturation.

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Statin therapy reduces the myc ...... hagy and phagosome maturation.

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Statin therapy reduces the myc ...... hagy and phagosome maturation.

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prefLabel

Statin therapy reduces the myc ...... hagy and phagosome maturation.

@en

Statin therapy reduces the myc ...... hagy and phagosome maturation.

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The Journal of Infectious Diseases

P1476

Statin therapy reduces the myc ...... phagy and phagosome maturation

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P2093

A David Marais

http://www.w3.org/2001/XMLSchema#string

Frank Brombacher

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Harukazu Suzuki

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Musa M Mhlanga

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Ramona Hurdayal

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Rethabile Khutlang

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Reto Guler

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P2860

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

Pleiotropic effects of statins

Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations

Mycobacterial persistence requires the utilization of host cholesterol

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome.

Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence

Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.

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10.1093/INFDIS/JIT550

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5

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209

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Suraj P Parihar

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2013-10-16T00:00:00Z

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257889758

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24133190

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P921

Mycobacterium tuberculosis