The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.
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Functional roles of Syk in macrophage-mediated inflammatory responsesTargeting the Fc receptor in autoimmune diseaseTreatment of allergic asthma: modulation of Th2 cells and their responsesReactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell FormationCLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In VivoBAY61-3606 affects the viability of colon cancer cells in a genotype-directed mannerAntibodies against CD20 or B-cell receptor induce similar transcription patterns in human lymphoma cell linesA spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cellsThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersBAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro.A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of SykQuantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells.The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.Getting Syk: spleen tyrosine kinase as a therapeutic target.Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.Central nervous system mast cells in peripheral inflammatory nociception.The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formationDesign, Synthesis and Evaluation of New 2, 6-Dihydroimidazo[1, 2-c]Pyrimido[5, 4-e]-Pyrimidine-5(3H)-thiones as Possible Antihistaminic/Antiasthmatic AgentsPriming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screenSpleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected CellsOsteosarcoma Phenotype Is Inhibited by 3,4-Methylenedioxy-β-nitrostyreneLynA regulates an inflammation-sensitive signaling checkpoint in macrophages.A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition.Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of Type 1 diabetesMonovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsivenessKinase inhibitors for the treatment of inflammatory and autoimmune disorders.Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation.Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21.Therapeutic prospect of Syk inhibitors.The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosisSynthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling
P2860
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P2860
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
The orally available spleen ty ...... irway inflammation in rodents.
@en
The orally available spleen ty ...... irway inflammation in rodents.
@nl
type
label
The orally available spleen ty ...... irway inflammation in rodents.
@en
The orally available spleen ty ...... irway inflammation in rodents.
@nl
prefLabel
The orally available spleen ty ...... irway inflammation in rodents.
@en
The orally available spleen ty ...... irway inflammation in rodents.
@nl
P2093
P356
P1476
The orally available spleen ty ...... irway inflammation in rodents.
@en
P2093
Hiroichi Nagai
Keisuke Takeshita
Kevin B Bacon
Kosuke Nakashima
Masako Sato
Michitaka Shichijo
Mina Ishimori
Noriyuki Yamamoto
Takeshi Yura
Toshio Kokubo
P304
P356
10.1124/JPET.103.052316
P407
P577
2003-05-23T00:00:00Z