The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones.
about
Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms.Neuroplasticity and major depression, the role of modern antidepressant drugsDepression pathogenesis and treatment: what can we learn from blood mRNA expression?Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expressionInteractions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings.Glucocorticoid receptor function in vitro in patients with major depression.Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression.The glucocorticoid receptor: part of the solution or part of the problem?Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline 'predictors' and longitudinal 'targets'.Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depressionIn vitro modulation of the glucocorticoid receptor by antidepressants.Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids.The glucocorticoid receptor: pivot of depression and of antidepressant treatment?A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice.Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice.Activation of cAMP-protein kinase A abrogates STAT5-mediated inhibition of glucocorticoid receptor signaling by interferon-alpha.Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor.Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line.Central nervous system (CNS) delivery of glucocorticoids is fine-tuned by saturable transporters at the blood-CNS barriers and nonbarrier regions.Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters.The Role of the Endocannabinoids in Suppression of the Hypothalamic-pituitary-adrenal Axis Activity by Doxepin.Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test.Psychopharmacological treatment of depression, anxiety, irritability and insomnia in patients receiving interferon-alpha: a prospective case series and a discussion of biological mechanisms.[The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression].Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration.Effect of sertraline on glucocorticoid sensitivity of mononuclear leukocytes in post-traumatic stress disorder.Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic.
P2860
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P2860
The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
@zh-hant
name
The antidepressant clomipramin ...... asts and rat primary neurones.
@en
The antidepressant clomipramin ...... asts and rat primary neurones.
@nl
type
label
The antidepressant clomipramin ...... asts and rat primary neurones.
@en
The antidepressant clomipramin ...... asts and rat primary neurones.
@nl
prefLabel
The antidepressant clomipramin ...... asts and rat primary neurones.
@en
The antidepressant clomipramin ...... asts and rat primary neurones.
@nl
P2093
P2860
P50
P356
P1476
The antidepressant clomipramin ...... asts and rat primary neurones.
@en
P2093
Andrew Makoff
Robert W Kerwin
P2860
P2888
P304
P356
10.1038/SJ.NPP.1300195
P407
P577
2003-05-07T00:00:00Z