In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
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The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor SuperfamilyCD137 and CD137L signals are main drivers of type 1, cell-mediated immune responsesCytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated miceExpression of 4-1BB and 4-1BBL in thymocytes during thymus regenerationA novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity.Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity.IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in miceSoluble CD27-pool in humans may contribute to T cell activation and tumor immunity.Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11bGr-1 Myeloid-derived Suppressor Cells.Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustionEffects of Astragalus polysaccharide on immune responses of porcine PBMC stimulated with PRRSV or CSFV.p85beta phosphoinositide 3-kinase regulates CD28 coreceptor functionBiphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells4-1BB signaling breaks the tolerance of maternal CD8+ T cells that are reactive with alloantigens.CD137-mediated immunotherapy for allergic asthma4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8+ T CellsEffector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggeringCD8+ T cell dysfunction and increase in murine gammaherpesvirus latent viral burden in the absence of 4-1BB ligandChemokines, costimulatory molecules and fusion proteins for the immunotherapy of solid tumors.Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthmaGenome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patientsMultiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunityCD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotypeT cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer.Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6C(hi) monocyte differentiation.CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic miceIFN-gamma-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivoUse of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities.Hypercostimulation through 4-1BB distorts homeostasis of immune cells.Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors.CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells.Memory T cells need CD28 costimulation to remember.Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged mice.Costimulation signals for memory CD8+ T cells during viral infections.Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunity.T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy.
P2860
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P2860
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@en
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@nl
type
label
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@en
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@nl
prefLabel
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@en
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@nl
P2093
P2860
P356
P1433
P1476
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.
@en
P2093
E Scott Halstead
John D Altman
Yvonne M Mueller
P2860
P304
P356
10.1038/NI798
P407
P577
2002-05-20T00:00:00Z