A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

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http://www.wikidata.org/entity/Q44502775
Grand challenges in cellular biochemistry: the "next-gen" biochemistryA phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients.PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumoursPhase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.Targeting hypoxia in the leukemia microenvironmentAKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemiaInitial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.Application of population pharmacokinetics for preclinical safety and efficacy studies.Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling.
P2860

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

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http://www.wikidata.org/entity/Q44502775
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2010 nî lūn-bûn
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2010年の論文
@ja
2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
@zh-hant
name
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@en
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@nl
type
label
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@en
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@nl
prefLabel
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@en
A combined pharmacokinetic mod ...... ces in clearance and toxicity.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P698
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A combined pharmacokinetic mod ...... nces in clearance and toxicity
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P698