Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
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Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase IStructure of the adenylation domain of NAD+-dependent DNA ligase fromStaphylococcus aureusStructural and Functional Studies of Aspergillus clavatus N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase,Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In VivoMolecular characterization of NAD+-dependent DNA ligase from Wolbachia endosymbiont of lymphatic filarial parasite Brugia malayiBiochemical and genetic analysis of the four DNA ligases of mycobacteriaStaphylococcus aureus DNA ligase: characterization of its kinetics of catalysis and development of a high-throughput screening compatible chemiluminescent hybridization protection assay.NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors.Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases.DNA ligases: progress and prospects.A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines.Homology modeling of NAD+-dependent DNA ligase of the Wolbachia endosymbiont of Brugia malayi and its drug target potential using dispiro-cycloalkanones.Chromosome demise in the wake of ligase-deficient replication.New advances in antibiotic development and discovery.Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system.Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms.Bacterial DNA replication enzymes as targets for antibacterial drug discovery.Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus.Solution NMR studies of Chlorella virus DNA ligase-adenylate.Escherichia coli DNA ligase B may mitigate damage from oxidative stress.Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase.Novel whole-cell antibiotic biosensors for compound discovery.Novel targets for antibiotics in Staphylococcus aureus.Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.Evaluation of NAD(+) -dependent DNA ligase of mycobacteria as a potential target for antibiotics.Cofactor binding modulates the conformational stabilities and unfolding patterns of NAD(+)-dependent DNA ligases from Escherichia coli and Thermus scotoductus.Fluorescence spectroscopic and calorimetry based approaches to characterize the mode of interaction of small molecules with DNA.Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA).Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.DNA Replication Fidelity in the Mycobacterium tuberculosis Complex.The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.Protein polarization driven by nucleoid exclusion of DnaK(HSP70)-substrate complexes.
P2860
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P2860
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@en
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@nl
type
label
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@en
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@nl
prefLabel
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@en
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@nl
P2093
P2860
P356
P1476
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.
@en
P2093
Dieter Häbich
Harald Labischinski
Heike Brötz-Oesterhelt
Igor Knezevic
Karl Ziegelbauer
Stephan Bartel
Thomas Lampe
Ute Warnecke-Eberz
P2860
P304
39435-39442
P356
10.1074/JBC.M306479200
P407
P577
2003-07-15T00:00:00Z