Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation.
about
Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelA molecular switch driving inactivation in the cardiac K+ channel HERGA KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance.Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions.Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1Gating charges in the activation and inactivation processes of the HERG channelMolecular mechanisms for drug interactions with hERG that cause long QT syndrome.Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic aciInsights into hERG K+ channel structure and function from NMR studies.Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels.Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome.Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathwayThe Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage.Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.Triazolyl azabicyclo[3.1.0]hexanes: A class of potent and selective dopamine D(3) receptor antagonists.Dynamic conformational changes of extracellular S5-P linkers in the hERG channel.Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels.The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels.Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.Temperature dependence of human ether-a-go-go-related gene K+ currents.
P2860
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P2860
Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@en
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@nl
type
label
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@en
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@nl
prefLabel
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@en
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@nl
P2093
P2860
P50
P356
P1476
Structure of the HERG K+ chann ...... -helix in C-type inactivation.
@en
P2093
Allan M Torres
Asne Bauskin
Catherine E Clarke
David J Smith
Jane A Bursill
Paramjit S Bansal
Paul F Alewood
Philip W Kuchel
Samuel N Breit
P2860
P304
42136-42148
P356
10.1074/JBC.M212824200
P407
P577
2003-08-05T00:00:00Z