Identification of genes modulated in multiple myeloma using genetically identical twin samples.
about
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaIdentification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicingSeliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myelomaVariations in genome-wide gene expression in identical twins - a study of primary osteoblast-like culture from female twins discordant for osteoporosisNovel therapeutic strategies for multiple myelomaSystematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivityTelomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo.Cyclin K and cyclin D1b are oncogenic in myeloma cells.New strategies in the treatment of multiple myeloma.Input of DNA microarrays to identify novel mechanisms in multiple myeloma biology and therapeutic applications.Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma.NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancerEffectiveness of targeted therapy as monotherapy or combined therapy in patients with relapsed or refractory multiple myeloma: a systematic review and meta-analysis.MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responsesHeteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells.Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profilesAngiopoietin-1 and myeloma-induced angiogenesis.Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.Angiogenic switch in multiple myeloma.Bioinformatics analyses of differentially expressed genes associated with bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome.Proteasome inhibition as a therapeutic strategy for hematologic malignancies.A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.Growth factors and antiapoptotic signaling pathways in multiple myeloma.Bone marrow angiogenesis in multiple myeloma.BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.Genome-wide identification of genetic determinants for the cytotoxicity of perifosine.Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy.Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myeloma.Potential for therapeutic manipulation of the UPR in disease.The molecular characterization and clinical management of multiple myeloma in the post-genome era.Caspase polymorphisms and genetic susceptibility to multiple myelomaDysfunctional homologous recombination mediates genomic instability and progression in myeloma.Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein ResponseA list of candidate cancer biomarkers for targeted proteomics.Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth.
P2860
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P2860
Identification of genes modulated in multiple myeloma using genetically identical twin samples.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Identification of genes modula ...... ically identical twin samples.
@en
Identification of genes modula ...... ically identical twin samples.
@nl
type
label
Identification of genes modula ...... ically identical twin samples.
@en
Identification of genes modula ...... ically identical twin samples.
@nl
prefLabel
Identification of genes modula ...... ically identical twin samples.
@en
Identification of genes modula ...... ically identical twin samples.
@nl
P2093
P50
P1433
P1476
Identification of genes modula ...... ically identical twin samples.
@en
P2093
Constantine Mitsiades
Daniel Auclair
Daniel Carrasco
Dharminder Chauhan
Faith Davies
Lief Bergsagel
Masood Shammas
Nicholas Mitsiades
Nikhil C Munshi
P304
P356
10.1182/BLOOD-2003-02-0402
P407
P577
2003-09-11T00:00:00Z