Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.
about
Bile acid transportersFXR signaling in the enterohepatic systemLigand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genesRegulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubulesObstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)Structural requirements of the human sodium-dependent bile acid transporter (hASBT): role of 3- and 7-OH moieties on binding and translocation of bile acids.Clinical application of transcriptional activators of bile salt transporters.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Ursodeoxycholic acid treatment of vanishing bile duct syndromes.Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro.Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets.Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistanceLithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.Farnesoid X receptor represses hepatic human APOA gene expression.Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytesRegulation of hepatic ABCC transporters by xenobiotics and in disease states.The keratin cytoskeleton in liver diseases.Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction.Endocrine and metabolic regulation of renal drug transporters.FXR and PXR: potential therapeutic targets in cholestasis.Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis.Ursodeoxycholic acid: Mechanism of action and novel clinical applications.Ursodeoxycholic acid decreases age-related adiposity and inflammation in miceBile-acid-induced cell injury and protectionCharacterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in miceOST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.Nuclear receptors as therapeutic targets in cholestatic liver diseases.The role of FXR in disorders of bile acid homeostasis.Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.Orphan nuclear receptors as targets for drug development.The impact of cholesterol and its metabolites on drug metabolism.Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.Bile acid transporters and regulatory nuclear receptors in the liver and beyondNuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.
P2860
Q24652624-2DC3EE49-E871-4B8B-8FA8-DDB996D4ADCBQ27014753-6F463729-B355-4EEC-AA33-43B73ACEB7A8Q28118994-36F2E2E5-0637-4548-AD04-71A3DD3640C0Q28280371-510E1F60-7855-4270-BA1B-46A37925A3A1Q28390004-2CB65BAA-3EF3-4EEE-AF8D-B38A2661E26EQ28579409-2EACEF6F-D889-4EC8-9E9E-8CF6DF081E0FQ30494047-761048AE-0D08-4DE7-96EA-B3329E5184ADQ33650932-A122BA6C-2C67-44FD-9BE3-37906A251E1FQ33709930-D15F68B6-0BDF-4B96-8CF5-71E0111454B5Q33714593-417E7927-5196-4E90-A01E-7BBE6A821AE9Q33866782-F49275EC-80C6-4155-9D88-91255BEF990CQ33869488-76488D9F-87AD-4F0C-8387-5DBA5461F992Q34017604-94BB81D1-A57F-475F-A23A-9E59DEBB1E71Q34456568-8D830B39-AAC7-496D-9D3C-19C2FA6E3BB5Q35087943-62E99539-CE46-4D60-BDCB-B77806757342Q35145151-A7A4DAD1-9589-4482-8110-C6FCB75C2A1DQ35187047-FF9E7C98-F5E5-4A25-919D-D6F904481BD3Q35579531-56FC193C-356E-4ACD-88F1-5C89C2C0F79CQ35690177-60343F4B-4193-4449-8B5C-23D67C62A7F7Q35923530-59CF13DF-B4D1-4AAA-9A34-B66354666B36Q35925486-A221B5A2-42DB-4E61-93A5-1DF60AB4C039Q36335726-7A1D7B1D-F208-45EA-BDA7-B48E1465E4ACQ36572561-33B55D39-3A6E-46E1-8DC3-DAB14ADE6197Q36606886-5CBD0214-1FFE-4B0D-AA4D-042996B494F8Q37012207-55E509DB-F097-467A-B19F-D4DCE5D5D0ACQ37024454-6573B5E7-176F-4B12-8FF7-C57495857D36Q37157813-12683905-E01E-4BBD-A4E1-D3CBF9DEF3B7Q37174035-74A222C2-A654-4CCE-8675-B4CD0671BB0CQ37195541-2612BBDD-0355-416F-A199-75D169402D3CQ37222442-347229E2-9F25-4989-BD77-47388ECC7CC4Q37227362-ABDCBCD5-6933-4F60-A15B-13E52A29499DQ37230857-DDBAE0CC-83D2-4050-A1CA-BF24B16A9940Q37300843-4151CD05-C737-47E3-93E7-445FBDC2EEC5Q37462634-42DE01A6-C378-40AB-8556-3A3EDB6EF738Q37725708-4B604F36-9E3F-4318-ABBB-FC3F7D1D231AQ37841609-90C23CE3-6052-4473-8462-BA2050666747Q37919924-28EFEBD0-E46F-4B9B-A9BE-4F393511D4C9Q38033967-F2DAB0A7-5A44-45AC-A8C3-603589A282DCQ38074991-741E22BC-07C2-49CD-8521-482C13E24A39Q39881960-3B90BA60-2DAE-40B8-9639-F4935165455A
P2860
Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@en
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@nl
type
label
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@en
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@nl
prefLabel
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@en
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@nl
P2093
P1476
Role of nuclear bile acid rece ...... e liver, kidney and intestine.
@en
P2093
Andrea Fuchsbichler
Dagmar Silbert
Frank J Gonzalez
Hanns-Ulrich Marschall
Helmut Denk
Martin Wagner
Michael Trauner
Peter Fickert
Silvia Arbeiter
P304
P356
10.1016/S0168-8278(03)00228-9
P577
2003-10-01T00:00:00Z