NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
about
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancerNKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaUbiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancerAndrogen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated regionLoss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesisSox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cellsAcetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growthLysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancermTOR complex 2 is required for the development of prostate cancer induced by Pten loss in micePhosphatase and Tensin Homologue: Novel Regulation by Developmental SignalingGenetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse modelsSIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferationConcurrent Down-Regulation of PTEN and NKX3.1 Expression in Iranian Patients with Prostate CancerAn integrative proteomics and interaction network-based classifier for prostate cancer diagnosisId4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTENIdentification of seven new prostate cancer susceptibility loci through a genome-wide association studyMYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathwaysHuman prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivoTissue slice grafts: an in vivo model of human prostate androgen signalingSystems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation.Molecular genetics of prostate cancer: new prospects for old challengesRank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures.Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Molecular pathways and targets in prostate cancerAntioxidant treatment promotes prostate epithelial proliferation in Nkx3.1 mutant mice.SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1.Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice.Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.A luminal epithelial stem cell that is a cell of origin for prostate cancerZinc Finger 280B regulates sGCα1 and p53 in prostate cancer cellsAndrogen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor modelCell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.Development of a peptide-drug conjugate for prostate cancer therapy.TNFα-mediated loss of β-catenin/E-cadherin association and subsequent increase in cell migration is partially restored by NKX3.1 expression in prostate cellsPten Regulates Epithelial Cytodifferentiation during Prostate Development.
P2860
Q21091136-D8E2EBA0-137D-4ABF-A9EA-81F53180D33AQ24300295-140DC0D7-7EFD-4893-929D-76F622908AB2Q24303410-285CB297-D228-47F5-9440-FC7A5A42115EQ24310439-1FB7EE0E-6D09-4061-AA69-F7465D5FE7A9Q24314277-1DB9A51E-A1FD-4162-AFAC-0CCF907D0B97Q24314483-1E9C7963-3B9F-44C8-BA10-7FDB5C42EFCAQ24316490-51F7D85D-6A39-4062-BD68-3CE97E596F9CQ24316493-05BF152A-5FC5-4B22-9AC1-94D00B7B6CD6Q24337240-43976EE7-E5F9-42B1-A3FD-F99C6E971BCDQ24658113-D484BC64-ADD5-46B6-915E-0BE93AEFE0F4Q26784590-7CE09FA7-7010-4235-B618-9778CA3FF093Q27311359-90B96129-AB6E-4654-8E7F-059E27ED5E7AQ28278236-D87E6A7E-D9C0-4170-8F2C-31BC695ED2B6Q28387281-ABFDBC42-7143-486A-8E9F-F58BF5776CE1Q28533442-9409FE80-81CB-4A7D-BBB1-A86542790ED2Q28592943-4EFCFA81-2A80-4C2A-8F1D-D22C4FD608C5Q29417022-D59AA600-DCDF-4F56-8352-F7CD73BDD5DAQ33535955-7A933DAE-D419-4CE7-8462-1B77C64AE926Q33597010-83153340-4202-4459-A503-F6E5C110D457Q33914421-8E262E23-0635-40F5-829F-07A42000F63EQ33947237-D751C16F-CA16-4424-80F1-C97054B00956Q34078166-977B1517-4D18-4EEA-ACA1-10AF638223FBQ34127462-2A8F06C9-F2E5-4996-8183-FD54A7B99597Q34146410-47AEC1E5-5572-4C6A-8EAC-66F6703A2AA5Q34195003-F3F6FD74-E10C-4443-9187-A4DE040D9338Q34365632-1F5955BD-7871-412F-B537-1B51A6CAFA90Q34450412-8D61EC97-0437-467E-A3AB-EA875A2FB0AEQ34614284-8AB6630A-49F6-434A-A89C-12291DAD7563Q34720933-058BE940-C259-4B83-B56A-11F4EBF78C27Q34722551-13472178-9B83-42AE-8B32-001EDA91526BQ34724225-CC17E020-630D-4150-AEF0-5A0B0780A6D8Q34786771-C072B006-0ACA-4B0D-9F47-387EA9C32098Q35001982-86C6132D-507F-4F5D-A8AF-83ECE6E8AB0AQ35043575-7C5C1BF3-F4E7-4649-82A2-827B9C7A123DQ35140092-47DC4C0B-6E82-40A5-A9A0-5A6C9818B71AQ35166311-E5F709B0-E539-4EA6-83A3-330727FD3A37Q35168294-0BF5D44C-20D0-4C72-850E-91CB2C1B2A00Q35184864-F2B83644-EF0F-4DC9-B01B-A7BA29341CCDQ35381933-966B7185-1153-4F95-9B9B-359B476083F9Q35664021-389BC7C9-151B-4F90-9D83-844ED38E2770
P2860
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@en
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@nl
type
label
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@en
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@nl
prefLabel
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@en
NKX3.1 stabilizes p53, inhibit ...... nitiation caused by PTEN loss.
@nl
P2093
P1433
P1476
NKX3.1 stabilizes p53, inhibit ...... initiation caused by PTEN loss
@en
P2093
Chun-Ju Chang
Martin E Gleave
Owen N Witte
Shunyou Wang
P304
P356
10.1016/J.CCR.2006.03.031
P50
P577
2006-05-01T00:00:00Z