How does product isotope effect prove the operation of a two-state "rebound" mechanism in C-H hydroxylation by cytochrome P450?

How does product isotope effect prove the operation of a two-state "rebound" mechanism in C-H hydroxylation by cytochrome P450?

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http://www.wikidata.org/entity/Q44626312
Elucidating the role of the proximal cysteine hydrogen-bonding network in ferric cytochrome P450cam and corresponding mutants using magnetic circular dichroism spectroscopy.Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental studySuicide Inhibition of Cytochrome P450 Enzymes by Cyclopropylamines via a Ring-Opening Mechanism: Proton-Coupled Electron Transfer Makes a Difference.Quantum mechanics/molecular mechanics modeling of regioselectivity of drug metabolism in cytochrome P450 2C9.Singlet versus Triplet Reactivity in an Mn(V)-Oxo Species: Testing Theoretical Predictions Against Experimental Evidence.Radical rebound mechanism in cytochrome P-450-catalyzed hydroxylation of the multifaceted radical clocks alpha- and beta-thujone.Mechanism and structure-reactivity relationships for aromatic hydroxylation by cytochrome P450.Nonheme iron mediated oxidation of light alkanes with oxone: characterization of reactive oxoiron(IV) ligand cation radical intermediates by spectroscopic studies and DFT calculations.Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.The rebound mechanism in catalytic C-H oxidation by MnO(tpp)Cl from DFT studies: electronic nature of the active species.Mechanistic elucidation of C-H oxidation by electron rich non-heme iron(IV)-oxo at room temperature.ortho-Hydroxylation of aromatic acids by a non-heme Fe(V)=O species: how important is the ligand design?Metabolism of halogenated alkanes by cytochrome P450 enzymes. Aerobic oxidation versus anaerobic reduction.A computational examination on the structure, spin-state energetics and spectroscopic parameters of high-valent Fe(IV)=NTs species.MD simulations and QM/MM calculations show that single-site mutations of cytochrome P450BM3 alter the active site's complexity and the chemoselectivity of oxidation without changing the active species.Does Substrate Positioning Affect the Selectivity and Reactivity in the Hectochlorin Biosynthesis Halogenase?
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How does product isotope effect prove the operation of a two-state "rebound" mechanism in C-H hydroxylation by cytochrome P450?

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http://www.wikidata.org/entity/Q44626312
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How does product isotope effec ...... roxylation by cytochrome P450?
@en
How does product isotope effec ...... roxylation by cytochrome P450?
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How does product isotope effec ...... roxylation by cytochrome P450?
@en
How does product isotope effec ...... roxylation by cytochrome P450?
@nl
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How does product isotope effec ...... roxylation by cytochrome P450?
@en
How does product isotope effec ...... roxylation by cytochrome P450?
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
How does product isotope effec ...... roxylation by cytochrome P450?
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698