Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.
about
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease familyCloning and characterization of complementary DNA for human tryptaseFormation of active monomers from tetrameric human beta-tryptaseMast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblastsActive monomers of human beta-tryptase have expanded substrate specificitiesThe B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pHDegranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblastsResearch upregulation of CD23 (FcepsilonRII) expression in human airway smooth muscle cells (huASMC) in response to IL-4, GM-CSF, and IL-4/GM-CSFThe Role of Mast Cell Specific Chymases and Tryptases in Tumor AngiogenesisMast cell proteoglycansEffect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activityGlycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptaseFate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the bloodPromiscuous processing of human alphabeta-protryptases by cathepsins L, B, and CDistribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion.Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.Trypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activityMast cell tryptase is a mitogen for cultured fibroblasts.Mast cell function: a new vision of an old cell.Mast cell proteases as pharmacological targetsTime course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis.Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation.Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.Mast cell tryptases and chymases in inflammation and host defense.Processing of human protryptase in mast cells involves cathepsins L, B, and C.Potent selective nonpeptidic inhibitors of human lung tryptase.Role of ICAM-1 in the aggregation and adhesion of human alveolar macrophages in response to TNF-alpha and INF-gamma.Intracellular proteoglycans.Selective thrombosis of tumor blood vessels in mammary adenocarcinoma implants in ratsHuman mast cell basic fibroblast growth factor in pulmonary fibrotic disordersTrypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence.A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.Mast cells and mastocytosis.Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.Mast cell tryptase and asthma.Allosteric control of βII-tryptase by a redox active disulfide bond.A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I.A single gene in mast cells encodes the core peptides of heparin and chondroitin sulfate proteoglycans.Beta-tryptase regulates IL-8 expression in airway smooth muscle cells by a PAR-2-independent mechanism.
P2860
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P2860
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh-hant
name
Regulation of tryptase from hu ...... zation of the active tetramer.
@en
Regulation of tryptase from hu ...... zation of the active tetramer.
@nl
type
label
Regulation of tryptase from hu ...... zation of the active tetramer.
@en
Regulation of tryptase from hu ...... zation of the active tetramer.
@nl
prefLabel
Regulation of tryptase from hu ...... zation of the active tetramer.
@en
Regulation of tryptase from hu ...... zation of the active tetramer.
@nl
P1476
Regulation of tryptase from hu ...... zation of the active tetramer.
@en
P2093
Bradford TR
Schwartz LB
P304
P407
P577
1986-06-01T00:00:00Z