Selection and coamplification of heterologous genes in mammalian cells.
about
Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretionProduction of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cellsCloning and expression of a human ATP-citrate lyase cDNABinding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidusIncorporation of Tick-Borne Encephalitis Virus Replicons into Virus-Like Particles by a Packaging Cell LineStructure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virusA novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifsInteraction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutationsAsymmetry adjacent to the collagen-like domain in rat liver mannose-binding proteinStoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activationIntraclonal protein expression heterogeneity in recombinant CHO cellsExpression and characterization of a codon-optimized blood coagulation factor VIII.Biophysical characterization of lithostathine. Evidences for a polymeric structure at physiological pH and a proteolysis mechanism leading to the formation of fibrils.High-level production of recombinant human lysosomal acid alpha-glucosidase in Chinese hamster ovary cells which targets to heart muscle and corrects glycogen accumulation in fibroblasts from patients with Pompe diseaseMerits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.LCR/MEL: a versatile system for high-level expression of heterologous proteins in erythroid cells.Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment.In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membraneExpression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation.Simple piggyBac transposon-based mammalian cell expression system for inducible protein production.Functional Importance of a Proteoglycan Coreceptor in Pathologic LymphangiogenesisRapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering.Generation of a Chinese hamster ovary cell line producing recombinant human glucocerebrosidase.Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody.Isolation, characterization and recombinant protein expression in Veggie-CHO: A serum-free CHO host cell line.Overview of protein expression by mammalian cells.Production of recombinant proteins in mammalian cells.Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.Microencapsulation of engineered cells to deliver sustained high circulating levels of interleukin-6 to study hepatocellular carcinoma progression.Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification.Recombinant expression and characterization of a novel fibronectin isoform expressed in cartilaginous tissues.Bioprocess applications of a Sindbis virus-based temperature-inducible expression system.Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein.pHi and serum regulate AE2-mediated Cl-/HCO3- exchange in CHOP cells of defined transient transfection status.Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cellsExpression of antibodies using single open reading frame (sORF) vector design: Demonstration of manufacturing feasibility.Intramolecular interactions of the regulatory region with the catalytic core in the plasma membrane calcium pump.
P2860
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P2860
Selection and coamplification of heterologous genes in mammalian cells.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Selection and coamplification of heterologous genes in mammalian cells.
@en
Selection and coamplification of heterologous genes in mammalian cells.
@nl
type
label
Selection and coamplification of heterologous genes in mammalian cells.
@en
Selection and coamplification of heterologous genes in mammalian cells.
@nl
prefLabel
Selection and coamplification of heterologous genes in mammalian cells.
@en
Selection and coamplification of heterologous genes in mammalian cells.
@nl
P1476
Selection and coamplification of heterologous genes in mammalian cells.
@en
P2093
Kaufman RJ
P304
P356
10.1016/0076-6879(90)85044-O
P407
P577
1990-01-01T00:00:00Z