FLT3 mutations in childhood acute lymphoblastic leukemia.
about
Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaMutant FLT3 signaling contributes to a block in myeloid differentiationDefective nonhomologous end joining blocks B-cell development in FLT3/ITD miceFLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.Childhood B-acute lymphoblastic leukemia: a genetic update.FLT3 Internal Tandem Duplication and D835 Mutations in Patients with Acute Lymphoblastic Leukemia and its Clinical SignificancePattern of chromosome involvement in childhood hyperdiploid pre-B-cell acute lymhoblastic leukemia cases from India.The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia.The Biology and Targeting of FLT3 in Pediatric Leukemia.Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia.Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.Vandetanib mediates anti-leukemia activity by multiple mechanisms and interacts synergistically with DNA damaging agents.A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cellsIdentification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in developmentMolecular genetic analysis of haematological malignancies: I. Acute leukaemias and myeloproliferative disorders.Emerging drugs for adult acute lymphoblastic leukaemia.Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN-AML) and FLT3ITD.Outcome of older adults with cytogenetically normal AML (CN-AML) and FLT3 mutationsEmerging Flt3 kinase inhibitors in the treatment of leukaemia.Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutationsMicroenvironment determines lineage fate in a human model of MLL-AF9 leukemia.RNAi screen for rapid therapeutic target identification in leukemia patients.Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials.Leukemia stem cells and human acute lymphoblastic leukemia.ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.Genomic approaches to small molecule discovery.Disease diversity and FLT3 mutations.Novel targeted drug therapies for the treatment of childhood acute leukemiaIntensified chemotherapy without SCT in infant ALL: results from COG P9407 (Cohort 3)Investigational drugs targeting FLT3 for leukemia.FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia.Molecular pathology of mixed-lineage leukemia.TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo.Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Novel targeted therapies in acute lymphoblastic leukemia.
P2860
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P2860
FLT3 mutations in childhood acute lymphoblastic leukemia.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
FLT3 mutations in childhood acute lymphoblastic leukemia.
@en
FLT3 mutations in childhood acute lymphoblastic leukemia.
@nl
type
label
FLT3 mutations in childhood acute lymphoblastic leukemia.
@en
FLT3 mutations in childhood acute lymphoblastic leukemia.
@nl
prefLabel
FLT3 mutations in childhood acute lymphoblastic leukemia.
@en
FLT3 mutations in childhood acute lymphoblastic leukemia.
@nl
P2093
P1433
P1476
FLT3 mutations in childhood acute lymphoblastic leukemia.
@en
P2093
Edward A Fox
John G Gribben
Lewis B Silverman
Meghann E Mabon
Scott A Armstrong
Stanley J Korsmeyer
Stephen E Sallan
P304
P356
10.1182/BLOOD-2003-07-2441
P407
P577
2003-12-11T00:00:00Z