Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
about
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevisThe ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityThe stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γThe glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liverASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanismPhosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Systematic analysis and nomenclature of mammalian F-box proteinsDisruption of the Fbxw8 gene results in pre- and postnatal growth retardation in miceControl of cell growth by the SCF and APC/C ubiquitin ligasesIsoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligaseIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesFbxw7 controls angiogenesis by regulating endothelial Notch activityDysregulation of ubiquitin ligases in cancerFBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradationFBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung developmentFbxw8 is essential for Cul1-Cul7 complex formation and for placental developmentThe Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformationInvestigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesThe canonical Notch signaling pathway: unfolding the activation mechanism.Histone deacetylase activity selectively regulates notch-mediated smooth muscle differentiation in human vascular cells.Notch inhibitors as a new tool in the war on cancer: a pathway to watch.Notch inhibition as a promising new approach to cancer therapy.Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools.Mutation analysis of hCDC4 in AML cells identifies a new intronic polymorphism.The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Turn It Down a NotchSent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Aberrant regulation of FBW7 in cancer.Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.FBXW7 mutations in melanoma and a new therapeutic paradigmFBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis.The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradationRole of Pirh2 in mediating the regulation of p53 and c-Myc.Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibilityCullins and cancer.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.
P2860
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P2860
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@en
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@nl
type
label
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@en
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@nl
prefLabel
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@en
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
@nl
P2093
P2860
P356
P1476
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
@en
P2093
Keiichi I Nakayama
Keiko Nakayama
Masaaki Nishiyama
Noriko Ishida
Ryoichiro Kageyama
Ryosuke Tsunematsu
Yasumasa Bessho
Yuichi Oike
P2860
P304
P356
10.1074/JBC.M312337200
P407
P577
2003-12-12T00:00:00Z