A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.
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Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to ThrombinThrombin.Thrombin a-chain: activation remnant or allosteric effector?Role of the A chain in thrombin functionA critical role for Gly25 in the B chain of human thrombin.Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of a novel Ala362 --> Thr (Prothrombin Vellore 1) mutation.The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding.
P2860
Q27647052-68A7E80D-7DD8-4F86-95E0-2D0C2EC3DA91Q36800534-129D4331-A8E3-4034-A0BD-2385CFBFA2B5Q38989460-AB9CE9BF-5D2B-44A9-B88A-D41707E24CEFQ41987240-8E829271-4989-4488-B99D-A4439EDC0CC3Q45213010-E221E37F-2403-4B5C-AD03-610DD34A0459Q46489328-7D7E7E87-4F77-467F-98A4-972BE32E6275Q46860761-2127A1AC-D1FF-4036-AC9E-9EA377519E50
P2860
A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@en
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@nl
type
label
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@en
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@nl
prefLabel
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@en
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@nl
P2093
P2860
P50
P356
P1476
A natural prothrombin mutant r ...... ivity of human alpha-thrombin.
@en
P2093
Andrea Carotti
Cosimo Altomare
Sepideh Akhavan
P2860
P304
13035-13043
P356
10.1074/JBC.M312430200
P407
P577
2004-01-13T00:00:00Z