about
CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOGShedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses.Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation.Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells.Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity?Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer.Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments.Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: an emerging role of protein-glycan interactions.Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate.Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications.Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL.Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape.Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms.Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction.Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways.Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase.Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis.A pivotal role for galectin-1 in fetomaternal tolerance.Control of dendritic cell maturation and function by triiodothyronine.Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.[How do protein-glycan interactions regulate T-cell physiology?].Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses.Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1.Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell deathNK cells modulate the cytotoxic activity generated by Mycobacterium leprae-hsp65 in leprosy patients: role of IL-18 and IL-13A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathwayMacrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation
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description
hulumtues
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հետազոտող
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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Juan M. Ilarregui
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P106
P1153
6506672918
P21
P31
P496
0000-0002-6871-6764