Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.
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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stabilityMolecular physiology of mammalian glucokinaseInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverPresent status of clinical deployment of glucokinase activatorsFunctional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensingContributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa ratsSmall molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humansAn allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolismComparative docking assessment of glucokinase interactions with its allosteric activatorsGlucokinase activators (GKAs) promise a new pharmacotherapy for diabetics.A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activatorsBiochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humansConformational transition pathway in the allosteric process of human glucokinase.Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.Glucokinase activators for diabetes therapy: May 2010 status reportEffects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice.Glucokinase activators in diabetes management.Discontinued drugs 2011: endocrine and metabolic.Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.Lack of glibenclamide response in a case of permanent neonatal diabetes caused by incomplete inactivation of glucokinaseEndogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent.Comment on: Stefanovski et al. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care 2012;35:1015-1020.Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions.Oligomeric interactions provide alternatives to direct steric modes of control of sugar kinase/actin/hsp70 superfamily functions by heterotropic allosteric effectors: inhibition of E. coli glycerol kinase.Anti-diabetic effects of lemon balm ( Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice.Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism.Pharmacodynamic effects of the oral glucokinase activator AZD6370 after single doses in healthy volunteers assessed with euglycaemic clamp.Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks.Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators.Coagulanolide modulates hepatic glucose metabolism in C57BL/KsJ-db/db mice.For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.
P2860
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P2860
Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@en
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@nl
type
label
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@en
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@nl
prefLabel
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@en
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@nl
P2093
P1433
P1476
Stimulation of hepatocyte gluc ...... lecule glucokinase activators.
@en
P2093
Brendan Leighton
Debra Carroll
Heather J Wightman
Helen L Vertigan
Ian D Waddell
Katy J Brocklehurst
Loranne Agius
Matthew P Coghlan
Rick A Davies
Susan Aiston
P304
P356
10.2337/DIABETES.53.3.535
P407
P577
2004-03-01T00:00:00Z