Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.

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Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors.

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Q46407013-E97097DE-4DAB-427B-BD19-7E3CFCA6D91C

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Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.

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http://www.wikidata.org/entity/Q44779421

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2004 nî lūn-bûn

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2004年の論文

@ja

2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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name

Site-directed targeting of pla ...... roach in rational drug design.

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Site-directed targeting of pla ...... roach in rational drug design.

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Item

label

Site-directed targeting of pla ...... roach in rational drug design.

@en

Site-directed targeting of pla ...... roach in rational drug design.

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Site-directed targeting of pla ...... roach in rational drug design.

@en

Site-directed targeting of pla ...... roach in rational drug design.

@nl

P1476

Site-directed targeting of pla ...... roach in rational drug design.

@en

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Bart De Taeye

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Griet Compernolle

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Structure of a serpin-protease complex shows inhibition by deformation

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type-1: implications for antibody-mediated PAI-1-neutralization and vitronectin-binding.

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro.

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization.

Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex.

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity.

Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies.

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20447-20450

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scholarly article

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10.1074/JBC.M401971200

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English

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279

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Paul Declerck

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2004-02-26T00:00:00Z

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6686530

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14988411

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Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.

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P2860

P2860

Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.

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type

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P1433

P1476

P2093

P2860

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P356

P407

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P5875

P698

P356

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P1476

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P304

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P407

P433

P478

P50

P577

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P698