Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium.
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The use of polyoxometalates in protein crystallography – An attempt to widen a well-known bottleneckImplications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapyThe Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine PhosphorylaseGlycal Formation in Crystals of Uridine Phosphorylase ,Active Site Conformational Dynamics in Human Uridine Phosphorylase 1The Crystal Structure of Streptococcus pyogenes Uridine Phosphorylase Reveals a Distinct Subfamily of Nucleoside PhosphorylasesA novel structural mechanism for redox regulation of uridine phosphorylase 2 activityX-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio choleraeHigh-syn conformation of uridine and asymmetry of the hexameric molecule revealed in the high-resolution structures of Shewanella oneidensis MR-1 uridine phosphorylase in the free form and in complex with uridineConcerted action of two subunits of the functional dimer of Shewanella oneidensis MR-1 uridine phosphorylase derived from a comparison of the C212S mutant and the wild-type enzymeBiochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus.Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state.A structural perspective on enzymes activated by monovalent cations.Role of Na+ and K+ in enzyme function.Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylasesInvestigation of the redox centres of periplasmic selenate reductase from Thauera selenatis by EPR spectroscopy.Induction of nucleoside phosphorylase in Enterobacter aerogenes and enzymatic synthesis of adenine arabinoside.Crystallization of uridine phosphorylase from Shewanella oneidensis MR-1 in the laboratory and under microgravity and preliminary X-ray diffraction analysis.Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil.Expression, purification, crystallization and preliminary X-ray structure analysis of Vibrio cholerae uridine phosphorylase in complex with thymidine.Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil.Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
P2860
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P2860
Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Crystal structures of Escheric ...... es and influence of potassium.
@en
Crystal structures of Escheric ...... es and influence of potassium.
@nl
type
label
Crystal structures of Escheric ...... es and influence of potassium.
@en
Crystal structures of Escheric ...... es and influence of potassium.
@nl
prefLabel
Crystal structures of Escheric ...... es and influence of potassium.
@en
Crystal structures of Escheric ...... es and influence of potassium.
@nl
P2093
P1476
Crystal structures of Escheric ...... es and influence of potassium.
@en
P2093
John F Cutfield
Sue M Cutfield
Tom T Caradoc-Davies
P304
P356
10.1016/J.JMB.2004.01.039
P407
P577
2004-03-01T00:00:00Z