Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). - Wikidata - wikimedia - TriplyDB

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

http://www.wikidata.org/entity/Q44790860

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Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal.p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors Gastrointestinal stromal tumor and its targeted therapeutics.Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.Therapeutic modulators of STAT signalling for human diseases Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line Frequent KIT mutations in human gastrointestinal stromal tumors.Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy.Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification.Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles.Resistance to c-Kit inhibitors in melanoma: insights for future therapies Gastrointestinal stromal tumor - an evolving concept.AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis.Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization An update on molecular genetics of gastrointestinal stromal tumours.Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth.Surgery for gastrointestinal stromal tumour in the post-imatinib era.A case and literature review of complicated gastrointestinal stromal tumors Gastrointestinal stromal tumours: an update.Modern treatment of gastric gastrointestinal stromal tumors.Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors.Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance.KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors.DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors?Molecular approaches to resolve diagnostic dilemmas: the case of gastrointestinal stromal tumor and leiomyosarcoma.Update on imatinib for gastrointestinal stromal tumors: duration of treatment.Gastrointestinal stromal tumors: key to diagnosis and choice of therapy.The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors.Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors Targeting HSP90 for cancer therapy.Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib

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Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

http://www.wikidata.org/entity/Q44790860

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2004 nî lūn-bûn

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Mechanisms of oncogenic KIT si ...... stinal stromal tumors (GISTs).

@en

Mechanisms of oncogenic KIT si ...... astrointestinal stromal tumors

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type

label

Mechanisms of oncogenic KIT si ...... stinal stromal tumors (GISTs).

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Mechanisms of oncogenic KIT si ...... astrointestinal stromal tumors

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Mechanisms of oncogenic KIT si ...... stinal stromal tumors (GISTs).

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Mechanisms of oncogenic KIT si ...... stinal stromal tumors (GISTs).

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Bryna McConarty

http://www.w3.org/2001/XMLSchema#string

Christopher D M Fletcher

http://www.w3.org/2001/XMLSchema#string

Dipak Panigrahy

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Fabiola Medeiros

http://www.w3.org/2001/XMLSchema#string

George D Demetri

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Jonathan A Fletcher

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Nora E Joseph

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P2860

Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer

STAT protein recruitment and activation in c-Kit deletion mutants

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.

Kit signal transduction.

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase.

Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase.

Src family kinases are involved in the differential signaling from two splice forms of c-Kit.

STAT3 and STAT5B are targets of two different signal pathways activated by hematopoietin receptors and control transcription via separate cytokine response elements.

Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia.

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10.1038/SJ.ONC.1207525

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22

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23

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Anette Duensing

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2004-05-01T00:00:00Z

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7936367

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