Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.
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Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changesA novel anti-HIV active integrase inhibitor with a favorable in vitro cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase metabolism profile.Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidationRecent advances in pharmacokinetic extrapolation from preclinical data to humans.Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferasesComparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases.Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sitesImproving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronanIdentification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst.Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats.Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse BrainS-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants.Neonatal development of hepatic UGT1A9: implications of pediatric pharmacokinetics.Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Regioselective glucuronidation of flavonols by six human UGT1A isoforms.Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5'-diphospho-glucuronosyltransferase isoformsDrug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases.Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility.Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism.Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism.UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers.4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate.Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.Substrate inhibition kinetics in drug metabolism reactions.Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights.Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.The role of drug metabolizing enzymes in clearance.Changes in drug transport and metabolism and their clinical implications in non-alcoholic fatty liver disease.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.
P2860
Q27334876-3CD11729-B8F9-48DA-ABC5-5F8F174C0FAFQ28474849-DEE32656-3D3F-461D-9EBB-AF8D108A9453Q30429621-0EB2D0DF-CC45-456E-93D2-418D321AF807Q31034463-ADC573C5-6E60-448D-85BD-A1D074B7567FQ31049599-4330B859-589A-4A75-9445-764015E0926EQ33160231-537B9458-9B13-4EA9-B599-7694DAE0C61BQ33574627-3E5A5EA6-0260-4E0C-B2EE-79FC1A347B0FQ33714571-A32BD001-3C00-42F4-86D0-D9AFD342736FQ34145464-7C9B5070-3B75-43C3-A7E0-3308892F88D2Q34185989-CE7AF744-8D16-46F2-965B-A6839F0F4BDEQ34325249-549719E7-127E-4714-95B9-D04986A3B4CEQ34360024-BAF3F865-9D14-4AC0-AE7D-26273D2E5AE4Q34482453-7672ECDF-B0A6-4B24-A4E5-8175BB97DCC6Q34571313-B0A8B57D-B016-4C43-BCD9-E1544784DC64Q35013124-5B42F092-2AC8-41F9-BAE9-6FF971B20F01Q35013544-4C7397CF-F8DF-48F8-B0EE-67B4C81BC49EQ35206080-7D607A4A-6F73-401B-B6D1-BEA3345BE456Q35745262-DABB80C2-B0E0-40C7-B660-3EE1DF81E83CQ35826926-286AFE6A-AEC4-4FD9-B8C0-7BDA09E481B7Q36022710-232CD09D-927D-40EE-ACDA-739B8F660AEFQ36057407-051A46B2-5CB9-4A91-8B6F-DBD3CEBF68BFQ36115752-26C74A0C-BB7F-470E-9C95-7B57F631F90AQ36132293-E5C918E3-F03E-413F-A7FC-AA55888A7932Q36185254-B91456FD-7586-4B4E-AA29-269EBDF7C279Q36321163-7847AD37-1BE3-44A5-865F-75D6C0ECB2C4Q36353657-17DFF434-4141-42EE-86E3-1AEBD738528CQ36406279-D9D73B27-2604-42DB-9E36-EB372CD5C200Q36497680-B54B083A-9BC2-4B01-8BF2-B84AEA57184FQ36738996-47A7FA5B-2CB3-478D-AA9C-F5C38212765CQ36792667-023480F0-15C6-4F73-9ABC-AE66165BE8F5Q37065986-E502B6C9-632D-4152-A7DE-F91D4CE74580Q37159255-920947F3-EBBA-48B5-9A6C-E38F8D391575Q37397801-11623B7D-9EED-4FF7-A285-9B4467700FB9Q37402758-00DDAEFF-46F1-4B62-A645-2C002B0DF9DCQ37941118-E1B70124-5252-4ED5-A8D2-C22277EFAF92Q38086603-56925551-6060-4066-9A6B-F748C5471CFDQ38104574-58C749EB-8C2D-45CD-BA48-EFAA8E7DFB24Q38176051-41EAEB75-27C7-4BE2-9504-45A880481D56Q38737633-2CC8A76A-E152-4422-912F-9F014F6C642BQ38799423-FC1FC3A1-4B43-4DA9-B2EF-5734DB065DBA
P2860
Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@en
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@nl
type
label
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@en
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@nl
prefLabel
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@en
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@nl
P2093
P356
P1476
Human udp-glucuronosyltransfer ...... by diclofenac and probenecid.
@en
P2093
Dione Gardner-Stephen
J Brian Houston
John O Miners
Verawan Uchaipichat
Xiao-Hui Guo
P304
P356
10.1124/DMD.32.4.413
P577
2004-04-01T00:00:00Z