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Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transitionFeeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspringAtorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent mannerInterventions to prevent maternal obesity before conception, during pregnancy, and post partum.Nurturing care: promoting early childhood development.Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable DiseasesEarly developmental conditioning of later health and disease: physiology or pathophysiology?Review: developmental origins of osteoporotic fracture.Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual.Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnanciesA complex behavioural change intervention to reduce the risk of diabetes and prediabetes in the pre-conception period in Malaysia: study protocol for a randomised controlled trial.Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring.ANRIL Promoter DNA Methylation: A Perinatal Marker for Later AdiposityImmune response gene profiles in the term placenta depend upon maternal muscle mass.Dietary protein restriction during F0 pregnancy in rats induces transgenerational changes in the hepatic transcriptome in female offspring.Evolution, development and timing of puberty.The life and health challenges of young Malaysian couples: results from a stakeholder consensus and engagement study to support non-communicable disease prevention.Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life.Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesisPrenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model.An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth.Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development.Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart.Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast.Animal models and programming of the metabolic syndrome.Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice.Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylatioFeeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring.Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles.Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin.Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.Developmental origins of osteoporosis: the role of maternal nutrition.Epigenetic gene promoter methylation at birth is associated with child's later adiposity.Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep.Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner.Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms.The developmental origins of the metabolic syndrome.Developmental origins of disease paradigm: a mechanistic and evolutionary perspective.Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's Survey.Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.
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հետազոտող
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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Mark A Hanson
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