Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.
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Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesDisruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion diseaseComparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases.The expanding universe of prion diseases.Structural elements regulating amyloidogenesis: a cholinesterase model system.Effect of Cu2+ on the oxidative folding of synthetic maurotoxin in vitro.Redox control of prion and disease pathogenesis.Evolutionary implications of metal binding features in different species' prion protein: an inorganic point of view.Copper binding extrinsic to the octarepeat region in the prion proteinMechanisms for copper acquisition, distribution and regulation.Calorimetric investigation of copper binding in the N-terminal region of the prion protein at low copper loading: evidence for an entropically favorable first binding event.Prion protein misfolding.Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.The cellular prion protein (PrP(C)): its physiological function and role in diseaseModulating amyloid self-assembly and fibril morphology with Zn(II)Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation.Ligand binding promotes prion protein aggregation--role of the octapeptide repeatsBoth Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH.Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptomsThe tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells.Therapeutic interventions ameliorating prion disease.Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach.Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunitiesDe novo mammalian prion synthesis.Prions and manganese: A maddening beast.Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.Metal attenuating therapies in neurodegenerative disease.Prion processing: a double-edged sword?The secret life of extracellular vesicles in metal homeostasis and neurodegeneration.A reassessment of copper(II) binding in the full-length prion proteinThe Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors.Nitroxide Spin-Labelling and Its Role in Elucidating Cuproprotein Structure and Function.Impact of SDS surfactant on the interactions of Cu(2+) ions with the amyloidogenic region of human prion protein.Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain.Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein.Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells.
P2860
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P2860
Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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name
Preferential Cu2+ coordination ...... c region of the prion protein.
@en
Preferential Cu2+ coordination ...... c region of the prion protein.
@nl
type
label
Preferential Cu2+ coordination ...... c region of the prion protein.
@en
Preferential Cu2+ coordination ...... c region of the prion protein.
@nl
prefLabel
Preferential Cu2+ coordination ...... c region of the prion protein.
@en
Preferential Cu2+ coordination ...... c region of the prion protein.
@nl
P2093
P2860
P356
P1476
Preferential Cu2+ coordination ...... c region of the prion protein.
@en
P2093
Christopher E Jones
David R Brown
John H Viles
Salama R Abdelraheim
P2860
P304
32018-32027
P356
10.1074/JBC.M403467200
P407
P577
2004-05-15T00:00:00Z